Development of mouse models of angiosarcoma driven by p53.
Animals
Antigens, CD
/ metabolism
Cadherins
/ metabolism
Cell Differentiation
Disease Models, Animal
Endothelial Cells
/ metabolism
Hemangiosarcoma
/ metabolism
Integrases
/ genetics
Mice
Receptor, Platelet-Derived Growth Factor beta
/ genetics
Recombination, Genetic
Tumor Suppressor Protein p53
/ genetics
Angiosarcoma
Genetically engineered mouse model
Lymphomas
Trp53
Tumour
Journal
Disease models & mechanisms
ISSN: 1754-8411
Titre abrégé: Dis Model Mech
Pays: England
ID NLM: 101483332
Informations de publication
Date de publication:
09 07 2019
09 07 2019
Historique:
received:
19
12
2018
accepted:
13
06
2019
pubmed:
22
6
2019
medline:
6
5
2020
entrez:
22
6
2019
Statut:
epublish
Résumé
Angiosarcomas are a rare group of tumours which have poor prognosis and limited treatment options. The development of new therapies has been hampered by a lack of good preclinical models. Here, we describe the development of an autochthonous mouse model of angiosarcoma driven by loss of p53 in VE-cadherin-expressing endothelial cells. Using
Identifiants
pubmed: 31221668
pii: dmm.038612
doi: 10.1242/dmm.038612
pmc: PMC6679377
pii:
doi:
Substances chimiques
Antigens, CD
0
Cadherins
0
Trp53 protein, mouse
0
Tumor Suppressor Protein p53
0
cadherin 5
0
Receptor, Platelet-Derived Growth Factor beta
EC 2.7.10.1
Cre recombinase
EC 2.7.7.-
Integrases
EC 2.7.7.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Cancer Research UK
ID : C6088/A12063
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C157/A15703
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103749
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C157/A9148
Pays : United Kingdom
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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