Resolvin D1 promotes the targeting and clearance of necroptotic cells.
Journal
Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
18
01
2019
accepted:
28
05
2019
revised:
30
04
2019
pubmed:
22
6
2019
medline:
2
7
2021
entrez:
22
6
2019
Statut:
ppublish
Résumé
Inflammation-resolution is a protective response that is mediated by specialized pro-resolving mediators (SPMs). The clearance of dead cells or efferocytosis is a critical cellular program of inflammation-resolution. Impaired efferocytosis can lead to tissue damage in prevalent human diseases, like atherosclerosis. Therefore understanding mechanisms associated with swift clearance of dead cells is of utmost clinical importance. Recently, the accumulation of necroptotic cells (NCs) was observed in human plaques and we postulated that this is due to defective clearance programs. Here we present evidence that NCs are inefficiently taken up by macrophages because they have increased surface expression of a well-known "don't eat me" signal called CD47. High levels of CD47 on NCs stimulated RhoA-pMLC signaling in macrophages that promoted "nibbling", rather than whole-cell engulfment of NCs. Anti-CD47 blocking antibodies limited RhoA-p-MLC signaling and promoted whole-cell NC engulfment. Treatment with anti-CD47 blocking antibodies to Ldlr
Identifiants
pubmed: 31222041
doi: 10.1038/s41418-019-0370-1
pii: 10.1038/s41418-019-0370-1
pmc: PMC7206090
doi:
Substances chimiques
resolvin D1
0
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
525-539Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL113208
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL144475
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM095467
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL136044
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL106173
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL119047
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL119587
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL110951
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141127
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA207725
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130304
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL119587
Pays : United States
Organisme : CIHR
Pays : Canada
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