Increased facial asymmetry in autism spectrum conditions is associated with symptom presentation.
autism
facial asymmetry
morphology
neurodevelopment
subgroups
Journal
Autism research : official journal of the International Society for Autism Research
ISSN: 1939-3806
Titre abrégé: Autism Res
Pays: United States
ID NLM: 101461858
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
05
02
2019
accepted:
05
06
2019
pubmed:
22
6
2019
medline:
22
9
2020
entrez:
22
6
2019
Statut:
ppublish
Résumé
A key research priority in the study of autism spectrum conditions (ASC) is the discovery of biological markers that may help to identify and elucidate etiologically distinct subgroups. One physical marker that has received increasing research attention is facial structure. Although there remains little consensus in the field, findings relating to greater facial asymmetry (FA) in ASC exhibit some consistency. As there is growing recognition of the importance of replicatory studies in ASC research, the aim of this study was to investigate the replicability of increased FA in autistic children compared to nonautistic peers. Using three-dimensional photogrammetry, this study examined FA in 84 autistic children, 110 typically developing children with no family history of the condition, and 49 full siblings of autistic children. In support of previous literature, significantly greater depth-wise FA was identified in autistic children relative to the two comparison groups. As a further investigation, increased lateral FA in autistic children was found to be associated with greater severity of ASC symptoms on the Autism Diagnostic Observation Schedule, second edition, specifically related to repetitive and restrictive behaviors. These outcomes provide an important and independent replication of increased FA in ASC, as well as a novel contribution to the field. Having confirmed the direction and areas of increased FA in ASC, these findings could motivate a search for potential underlying brain dysmorphogenesis. Autism Res 2019, 12: 1774-1783. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study looked at the amount of facial asymmetry (FA) in autistic children compared to typically developing children and children who have siblings with autism. The study found that autistic children, compared to the other two groups, had greater FA, and that increased FA was related to greater severity of autistic symptoms. The face and brain grow together during the earliest stages of development, and so findings of facial differences in autism might inform future studies of early brain differences associated with the condition.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1774-1783Subventions
Organisme : National Health and Medical Research Council Senior Research Fellowship
ID : APP1077966
Pays : International
Organisme : Cooperative Research Centre for Living with Autism
Pays : International
Informations de copyright
© 2019 International Society for Autism Research, Wiley Periodicals, Inc.
Références
Al Ali, A., Richmond, S., Popat, H., Toma, A. M., Playle, R., Zhurov, A. I., … Henderson, J. (2014). The influence of asthma on face shape: A three-dimensional study. European Journal of Orthodontics, 36, 373-380. https://doi.org/10.1093/ejo/cjs067
Aldridge, K., Boyadjiev, S. A., Capone, G. T., DeLeon, V. B., & Richtsmeier, J. T. (2005). Precision and error of three-dimensional phenotypic measures acquired from 3dMD photogrammetric images. American Journal of Medical Genetics, 138A, 247-253. https://doi.org/10.1002/ajmg.a.30959
Aldridge, K., George, I. D., Cole, K. K., Austin, J. R., Takahashi, T. N., Duan, Y., & Miles, J. H. (2011). Facial phenotypes in subgroups of prepubertal boys with autism spectrum disorders are correlated with clinical phenotypes. Molecular Autism, 2(1), 15. https://doi.org/10.1186/2040-2392-2-15
Bloch, M. H., Leckman, J. F., Zhu, H., & Peterson, B. S. (2005). Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome. Neurology, 65, 1253-1258. https://doi.org/10.1212/01.wnl.0000180957.98702.69
Boutrus, M., Maybery, M. T., Alvares, G. A., Tan, D. W., Varcin, K. J., & Whitehouse, A. J. O. (2017). Investigating facial phenotype in autism spectrum conditions: The importance of a hypothesis driven approach. Autism Research, 10, 1-9. https://doi.org/10.1002/aur.1824
Brambilla, P., Hardan, A., Ucelli Di Nemi, S., Perez, J., Soares, J. C., & Barale, F. (2003). Brain anatomy and development in autism: Review of structural MRI studies. Brain Research Bulletin, 61, 557-569. https://doi.org/10.1016/j.brainresbull.2003.06.001
Cheung, C., McAlonan, G. M., Fung, Y. Y., Fung, G., Yu, K. K., Tai, K. S., … Chua, S. E. (2011). Mri study of minor physical anomaly in childhood autism implicates aberrant neurodevelopment in infancy. PLoS One, 6(6), e20246. https://doi.org/10.1371/journal.pone.0020246
Chinthapalli, K., Bartolini, E., Novy, J., Suttie, M., Marini, C., Falchi, M., … Sisodiya, S. M. (2012). Atypical face shape and genomic structural variants in epilepsy. Brain, 135, 3101-3114. https://doi.org/10.1093/brain/aws232
Chiu, Y. E., Vora, S., Kwon, E. K. M., & Maheshwari, M. (2012). A significant proportion of children with morphea en coup de sabre and Parry-Romberg syndrome have neuroimaging findings. Pediatric Dermatology, 29, 738-748. https://doi.org/10.1111/pde.12001
Courchesne, E., Müller, R. A., & Saitoh, O. (1999). Brain weight in autism: Normal in the majority of cases, megalencephalic in rare cases. Neurology, 52, 1057-1059.
DeMyer, W., Zeman, W., & Palmer, C. (1964). The face predicts the brain: Diagnostic significance of median facial anomalies for holoprosencephaly (arhinencephaly). Pediatrics, 34, 256-263.
Ecker, C., Bookheimer, S. Y., & Murphy, D. G. M. (2015). Neuroimaging in autism spectrum disorder: Brain structure and function across the lifespan. The Lancet Neurology, 14, 1121-1134. https://doi.org/10.1016/S1474-4422(15)00050-2
Farkas, L. G., & Posnick, J. C. (1992). Growth and development of regional units in the head and face based on anthropometric measurements. Cleft Palate-Craniofacial Journal, 29, 301-302. https://doi.org/10.1597/1545-1569(1992)029<0301:GADORU>2.3.CO;2
Gilani, S. Z., Mian, A., Shafait, F., & Reid, I. (2018). Dense 3D Face Correspondence. IEEE Transactions on Pattern Analysis and Machine Intelligence, 40, 1584-1598. https://doi.org/10.1109/TPAMI.2017.2725279
Gotham, K., Pickles, A., & Lord, C. (2009). Standardizing ADOS scores for a measure of severity in autism spectrum disorders. Journal of Autism and Developmental Disorders, 39, 693-705. https://doi.org/10.1007/s10803-008-0674-3
Graham, J., & Özener, B. (2016). Fluctuating asymmetry of human populations: a review. Symmetry, 8, 154. https://doi.org/10.3390/sym8120154
Hammond, P., Forster-Gibson, C., Chudley, A. E., Allanson, J. E., Hutton, T. J., Farrell, S. A., … Lewis, M. E. S. (2008). Face-brain asymmetry in autism spectrum disorders. Molecular Psychiatry, 13(6), 614-623. https://doi.org/10.1038/mp.2008.18
Hardan, A. Y., Keshavan, M. S., Sreedhar, S., Vemulapalli, M., & Minshew, N. J. (2006). An MRI study of minor physical anomalies in autism. Journal of Autism and Developmental Disorders, 36(5), 607-611. https://doi.org/10.1007/s10803-006-0103-4
Hattier, M. A., Matson, J. L., Tureck, K., & Horovitz, M. (2011). The effects of gender and age on repetitive and/or restricted behaviors and interests in adults with autism spectrum disorders and intellectual disability. Research in Developmental Disabilities, 32, 2346-2351. https://doi.org/10.1016/j.ridd.2011.07.028
Herbert, M. R., Ziegler, D. A., Deutsch, C. K., O'Brien, L. M., Kennedy, D. N., Filipek, P. A., … Caviness, V. S. (2005). Brain asymmetries in autism and developmental language disorder: A nested whole-brain analysis. Brain, 128, 213-226. https://doi.org/10.1093/brain/awh330
Herbert, M. R., Ziegler, D. A., Makris, N., Filipek, P. A., Kemper, T. L., Normandin, J. J., … Caviness, V. S. (2004). Localization of white matter volume increase in autism and developmental language disorder. Annals of Neurology, 55, 530-540. https://doi.org/10.1002/ana.20032
Hollander, E., Anagnostou, E., Chaplin, W., Esposito, K., Haznedar, M. M., Licalzi, E., … Buchsbaum, M. (2005). Striatal volume on magnetic resonance imaging and repetitive behaviors in autism. Biological Psychiatry, 58, 226-232. https://doi.org/10.1016/j.biopsych.2005.03.040
Lainhart, J. E., Piven, J., Wzorek, M., Landa, R., Santangelo, S. L., Coon, H., & Folstein, S. E. (1997). Macrocephaly in children and adults with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 282-290. https://doi.org/10.1097/00004583-199702000-00019
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., … Rutter, M. (2012). Autism diagnostic observation schedule, second edition (ADOS-2). Journal of Autism and Developmental Disorders, 19, 185-212. https://doi.org/10.1007/BF02211841
Manouilenko, I., Eriksson, J. M., Humble, M. B., & Bejerot, S. (2014). Minor physical anomalies in adults with autism spectrum disorder and healthy controls. Autism Research and Treatment, 2014, 1-10. https://doi.org/10.1155/2014/743482
Marcucio, R., Hallgrimsson, B., & Young, N. M. (2015). Facial morphogenesis: Physical and molecular interactions between the brain and the face. Current Topics in Developmental Biology, 115, 299-320. https://doi.org/10.1016/bs.ctdb.2015.09.001
Müller, R. A., & Amaral, D. G. (2017). Editorial: Time to give up on autism spectrum disorder? Autism Research, 10(1), 10-14. https://doi.org/10.1002/aur.1746
Nellhaus, G. (1968). Head circumference from birth to eighteen years. Practical composite international and interracial graphs. Pediatrics, 41, 106-114.
Nordahl, C. W., Lange, N., Li, D. D., Barnett, L. A., Lee, A., Buonocore, M. H., … Amaral, D. G. (2011). Brain enlargement is associated with regression in preschool-age boys with autism spectrum disorders. Proceedings of the National Academy of Sciences, 108, 20195-20200. https://doi.org/10.1073/pnas.1107560108
Ohdo, S., Madokoro, H., & Sonoda, T. (1986). Incidence of minor physical anomalies in patients with early infantile autism. Pediatrics International, 28, 633-638.
Ozgen, H., Hellemann, G. S., De Jonge, M. V., Beemer, F. A., & Van Engeland, H. (2013). Predictive value of morphological features in patients with autism versus normal controls. Journal of Autism and Developmental Disorders, 43(1), 147-155. https://doi.org/10.1007/s10803-012-1554-4
Ozgen, H., Hellemann, G. S., Stellato, R. K., Lahuis, B., Van Daalen, E., Staal, W. G., … Van Engeland, H. (2011). Morphological features in children with autism spectrum disorders: A matched case-control study. Journal of Autism and Developmental Disorders, 41(5), 23-31. https://doi.org/10.1007/s10803-010-1018-7
Pisula, E., & Ziegart-Sadowska, K. (2015). Broader autism phenotype in siblings of children with asd-A review. International Journal of Molecular Sciences, 16, 13217-13258. https://doi.org/10.3390/ijms160613217
Piven, J., Arndt, S., Bailey, J., Havercamp, S., Andreasen, N. C., & Palmer, P. (1995). An MRI study of brain size in autism. American Journal of Psychiatry, 152, 1145-1149. https://doi.org/10.1176/ajp.152.8.1145
Rodier, P. M., Bryson, S. E., & Welch, J. P. (1997). Minor malformations and physical measurements in autism: Data from Nova Scotia. Teratology, 55, 319-325. https://doi.org/10.1002/(SICI)1096-9926(199705)55:5<319::AID-TERA4>3.0.CO;2-U
Rojas, D. C., Peterson, E., Winterrowd, E., Reite, M. L., Rogers, S. J., & Tregellas, J. R. (2006). Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms. BMC Psychiatry, 6, 56. https://doi.org/10.1186/1471-244X-6-56
Scarone, S., Colombo, C., Livian, S., Abbruzzese, M., Ronchi, P., Locatelli, M., … Smeraldi, E. (1992). Increased right caudate nucleus size in obsessive-compulsive disorder: Detection with magnetic resonance imaging. Psychiatry Research: Neuroimaging, 45, 115-121. https://doi.org/10.1016/0925-4927(92)90005-O
Shprintzen, R. J., Higgins, A. M., Antshel, K., Fremont, W., Roizen, N., & Kates, W. (2005). Velo-cardio-facial syndrome. Current Opinion in Pediatrics, 17, 725-730. https://doi.org/10.1097/01.mop.0000184465.73833.0b
Solomon, M., Miller, M., Taylor, S. L., Hinshaw, S. P., & Carter, C. S. (2012). Autism symptoms and internalizing psychopathology in girls and boys with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42, 48-59. https://doi.org/10.1007/s10803-011-1215-z
Tan, D. W., Gilani, S. Z., Maybery, M. T., Mian, A., Hunt, A., Walters, M., & Whitehouse, A. J. O. (2017). Hypermasculinised facial morphology in boys and girls with autism spectrum disorder and its association with symptomatology. Scientific Reports, 7, 9348. https://doi.org/10.1038/s41598-017-09939-y
Tripi, G., Roux, S., Canziani, T., Brilhault, F. B., Barthélémy, C., & Canziani, F. (2008). Minor physical anomalies in children with autism spectrum disorder. Early Human Development, 84(4), 217-223.
Walker, H. A. (1977). Incidence of minor physical anomaly in autism. Journal of Autism and Childhood Schizophrenia, 7(2), 165-176. https://doi.org/10.1007/BF01537727
Weinberg, S. M., Scott, N. M., Neiswanger, K., Brandon, C. A., & Marazita, M. L. (2004). Digital three-dimensional photogrammetry: Evaluation of anthropometric precision and accuracy using a Genex 3D camera system. Cleft Palate-Craniofacial Journal, 41, 507-518. https://doi.org/10.1597/03-066.1
Whitehouse, A. J. O., Cooper, M. N., Bebbington, K., Alvares, G., Lin, A., Wray, J., & Glasson, E. J. (2017). Evidence of a reduction over time in the behavioral severity of autistic disorder diagnoses. Autism Research, 10, 179-187. https://doi.org/10.1002/aur.1740
Wilson, J. M., & Manning, J. T. (1996). Fluctuating asymmetry and age in children: Evolutionary implications for the control of developmental stability. Journal of Human Evolution, 30(6), 529-537. https://doi.org/10.1006/jhev.1996.0041