Epstein-barr virus and multiple sclerosis risk in the finnish maternity cohort.
Adult
Antibodies, Viral
/ blood
Case-Control Studies
Child of Impaired Parents
Cotinine
/ blood
Cytomegalovirus
/ immunology
Epstein-Barr Virus Nuclear Antigens
/ immunology
Female
Finland
Herpesvirus 4, Human
/ immunology
Humans
Immunoglobulin G
/ blood
Male
Mothers
Multiple Sclerosis
/ virology
Pregnancy
Prospective Studies
Risk Factors
Vitamin D
/ analogs & derivatives
Young Adult
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
21
02
2019
revised:
28
05
2019
accepted:
17
06
2019
pubmed:
22
6
2019
medline:
14
4
2020
entrez:
22
6
2019
Statut:
ppublish
Résumé
To determine whether maternal Epstein-Barr virus (EBV) IgG antibody levels are associated with risk of multiple sclerosis (MS) in the offspring. We conducted a prospective nested case-control study in the Finnish Maternity Cohort (FMC) with serum samples from >800,000 women collected during pregnancy since 1983. Cases of MS among offspring born between 1983 and 1991 were identified via hospital and prescription registries; 176 cases were matched to up to 3 controls (n = 326) on region and dates of birth, sample collection, and mother's birth. We used conditional logistic regression to estimate relative risks (RRs) and adjusted models for sex of the child, gestational age at sample collection, and maternal serum 25-hydroxyvitamin D and cotinine levels. Similar analyses were conducted among 1,049 women with MS and 1,867 matched controls in the FMC. Maternal viral capsid antigen IgG levels during pregnancy were associated with an increased MS risk among offspring (RR Offspring of mothers with high viral capsid antigen IgG during pregnancy appear to have an increased risk of MS. The increase in MS risk among women with elevated prediagnostic EBNA-1 IgG levels is consistent with previous results. ANN NEUROL 2019;86:436-442.
Identifiants
pubmed: 31226219
doi: 10.1002/ana.25532
pmc: PMC6839107
mid: NIHMS1057148
doi:
Substances chimiques
Antibodies, Viral
0
Epstein-Barr Virus Nuclear Antigens
0
Immunoglobulin G
0
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
Cotinine
K5161X06LL
EBV-encoded nuclear antigen 1
O5GA75RST7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
436-442Subventions
Organisme : NINDS NIH HHS
ID : R01 NS073633
Pays : United States
Informations de copyright
© 2019 American Neurological Association.
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