Effects of pharmacological lesion of the nucleus retroambiguus region on the pharyngeal phase of swallowing.
Animals
Deglutition
/ physiology
Electric Stimulation
Female
GABA-A Receptor Agonists
/ administration & dosage
Laryngeal Nerves
/ physiology
Male
Medulla Oblongata
/ drug effects
Pharynx
/ physiology
Phrenic Nerve
/ physiology
Rats
Rats, Sprague-Dawley
Respiration
Sensory Gating
/ physiology
Vagus Nerve
/ physiology
Brainstem
Larynx
Sensory gating
Superior laryngeal nerve
Swallowing breathing coordination
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
06
02
2019
revised:
07
06
2019
accepted:
08
06
2019
pubmed:
22
6
2019
medline:
13
5
2020
entrez:
22
6
2019
Statut:
ppublish
Résumé
Pharyngeal swallowing is controlled by synaptic interactions within a swallowing central pattern generator (sw-CPG) that is composed of a dorsal and a ventral swallowing group (VSG). Here, we used electrical stimulation (10 s) of the superior laryngeal nerve (SLN; 20 Hz; pulse width: 100 μs) to explore the role of the VSG in an arterially-perfused brainstem preparation of rats. To investigate the effects of pharmacological lesion (local microinjection of an GABA(A)-R agonist) of the nucleus retroambiguus (NRA), a designated component of the VSG, we recorded phrenic (PNA) and vagal nerve (VNA) activities. Control SLN stimulation with stepwise increasing stimulus intensities (from 20 μA to 160 μA) elicited robust suppression of PNA and evoked sequential swallowing activity in the VNA. Lesioning of the NRA had no effect on the pattern of pharyngeal swallowing, but significantly increased the sensory gating of SLN inputs. We conclude that the NRA is not part of the VSG, but appears to have important roles for the central gating of swallowing.
Identifiants
pubmed: 31226424
pii: S1569-9048(19)30040-0
doi: 10.1016/j.resp.2019.06.001
pii:
doi:
Substances chimiques
GABA-A Receptor Agonists
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103244Informations de copyright
Copyright © 2019. Published by Elsevier B.V.