Medication use in infants with severe bronchopulmonary dysplasia admitted to United States children's hospitals.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
21
03
2019
accepted:
20
05
2019
pubmed:
23
6
2019
medline:
6
5
2020
entrez:
23
6
2019
Statut:
ppublish
Résumé
To identify the number of cumulative medication exposures and most frequently used medications in infants with severe BPD. We performed a retrospective cohort study in infants with severe BPD admitted to United States children's hospitals. We measured cumulative medication exposures in individual subjects and between-center variation after adjustment for infant characteristics. We then identified the specific medications and therapeutic classes with the highest rates of use. In 3252 subjects across 43 hospitals, we identified a median (interquartile range) of 30 (17-45) cumulative medication exposures per infant. The adjusted mean number of medication exposures varied between centers (p < 0.0001), with a range of 22-50. Diuretics and furosemide were the most frequently prescribed therapeutic class and specific medication for the management of severe BPD. Infants with severe BPD are exposed to alarming number of medications of unclear efficacy and safety, with marked variation between center.
Identifiants
pubmed: 31227785
doi: 10.1038/s41372-019-0415-9
pii: 10.1038/s41372-019-0415-9
pmc: PMC6713592
mid: NIHMS1529958
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1291-1299Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL136843
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : K23HL136843
Pays : International
Organisme : NICHD NIH HHS
ID : T32 HD060550
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL143283
Pays : United States
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : 2T32HD060550-06
Pays : International
Commentaires et corrections
Type : CommentIn
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