Beneficial role of adipose-derived mesenchymal stem cells from microfragmented fat in a murine model of duchenne muscular dystrophy.

Adipose Tissue / pathology Animals Disease Models, Animal Dystrophin / genetics Mesenchymal Stem Cells / cytology Mice, Inbred C57BL Muscle Strength / physiology Muscle, Skeletal / pathology Muscular Dystrophy, Duchenne / genetics
Duchenne muscular dystrophy adipose-derived mesenchymal stem cells mesenchymal stem cells microfragmented fat stem cells

Journal

Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146

Informations de publication

Date de publication:
09 2019
Historique:
received: 08 01 2018
revised: 12 06 2019
accepted: 16 06 2019
pubmed: 23 6 2019
medline: 10 1 2020
entrez: 23 6 2019
Statut: ppublish

Résumé

No etiologic therapy is available for Duchenne muscular dystrophy (DMD), but mesenchymal stem cells were shown to be effective in preclinical models of DMD. The objective of this study is to investigate the effect of microfragmented fat extracted on a murine model of DMD. Fat tissue was extracted from healthy human participants and injected IM into DMD mice. Histological analysis, cytokines, and force measurement were performed up to 4 weeks after injection. Duchenne muscular dystrophy mice injected with microfragmented fat exhibited an improved muscle phenotype (decreased necrosis and fibrosis), a decrease of inflammatory cytokines, and increased strength. Administration of microfragmented fat in key muscles may improve muscular phenotype in patients with DMD. Muscle Nerve, 2019.

Identifiants

DOI: 10.1002/mus.26614 PMID: 31228273
pubmed: 31228273
doi: 10.1002/mus.26614
doi:

Substances chimiques

Dystrophin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

328-335

Informations de copyright

© 2019 Wiley Periodicals, Inc.

Auteurs

Adrien Bouglé (A)

Infection and Epidemiology Department, Experimental Neuropathology Unit, Institut Pasteur, Paris, France.
Sorbonne Université, Assistance Publique - Hôpitaux de Paris, Department of Anesthesiology and Critical Care Medicine, Pitié-Salpêtrière Hospital, Paris, France.
Assistance Publique-Hôpitaux de Paris, Paris, France.
Department of Anesthesiology and Critical Care Medicine, Institute of Cardiology, Pitié-Salpêtrière Hospital, Paris, France.

Pierre Rocheteau (P)

Infection and Epidemiology Department, Experimental Neuropathology Unit, Institut Pasteur, Paris, France.
Service Hospitalo-Universitaire, Centre Hospitalier Sainte Anne, Paris, France.
Laboratoire Universitaire de Neuropathologie, Centre Hospitalier Sainte Anne, Paris, France.

David Briand (D)

Infection and Epidemiology Department, Experimental Neuropathology Unit, Institut Pasteur, Paris, France.

David Hardy (D)

Infection and Epidemiology Department, Experimental Neuropathology Unit, Institut Pasteur, Paris, France.

Franck Verdonk (F)

Infection and Epidemiology Department, Experimental Neuropathology Unit, Institut Pasteur, Paris, France.
Sorbonne Université, Assistance Publique - Hôpitaux de Paris, Department of Anesthesiology and Critical Care Medicine, Pitié-Salpêtrière Hospital, Paris, France.
Assistance Publique-Hôpitaux de Paris, Paris, France.
Department of Anesthesiology and Critical Care Department, Saint-Antoine Hospital, Paris, France.

Carlo Tremolada (C)

Image Institute, Milan, Italy.

Mikael Hivelin (M)

Assistance Publique-Hôpitaux de Paris, Paris, France.
Descartes University, Assistance Publique - Hôpitaux de Paris, Department of Plastic Surgery, Hôpital Européen Georges Pompidou, Paris, France.
Department of Plastic Surgery, Hôpital Européen Georges Pompidou, Paris, France.

Fabrice Chrétien (F)

Infection and Epidemiology Department, Experimental Neuropathology Unit, Institut Pasteur, Paris, France.
Laboratoire Universitaire de Neuropathologie, Centre Hospitalier Sainte Anne, Paris, France.
Descartes University, Assistance Publique - Hôpitaux de Paris, Department of Plastic Surgery, Hôpital Européen Georges Pompidou, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Beneficial role of adipose-derived mesenchymal...
questionsmedicales.fr › Eucaryotes › Animaux › Beneficial role of adipose-derived mesenchymal...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Beneficial role of adipose-derived mesenchymal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Dystrophine › Beneficial role of adipose-derived mesenchymal...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Beneficial role of adipose-derived mesenchymal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Beneficial role of adipose-derived mesenchymal...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Force musculaire › Beneficial role of adipose-derived mesenchymal...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Beneficial role of adipose-derived mesenchymal...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Dystrophies musculaires › Myopathie de Duchenne › Beneficial role of adipose-derived mesenchymal...