Cell and tissue response to nanotextured Ti6Al4V and Zr implants using high-speed femtosecond laser-induced periodic surface structures.
Cell proliferation
Femtosecond laser
Fluorescence
HR-LIPSS
Nanotexturing
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
29
01
2019
revised:
27
04
2019
accepted:
02
06
2019
pubmed:
23
6
2019
medline:
26
6
2020
entrez:
23
6
2019
Statut:
ppublish
Résumé
In this paper, the effect of femtosecond laser nanotexturing of surfaces of Ti6Al4V and Zr implants on their biological compatibility is presented and discussed. Highly regular and homogeneous nanostructures with sub-micrometer period were imprinted on implant surfaces. Surfaces were morphologically and chemically investigated by SEM and XPS. HDFa cell lines were used for toxicity and cell viability tests, and subcutaneous implantation was applied to characterize tissue response. HDFa proliferation and in vivo experiments evidenced the strong influence of the surface topography compared to the effect of the surface elemental composition (metal or alloy). The effect of protein adsorption from blood plasma on cell proliferation is also discussed.
Identifiants
pubmed: 31228604
pii: S1549-9634(19)30120-0
doi: 10.1016/j.nano.2019.102036
pii:
doi:
Substances chimiques
Alloys
0
titanium alloy (TiAl6V4)
12743-70-3
Zirconium
C6V6S92N3C
Titanium
D1JT611TNE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102036Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.