Long-term observational study on the impact of GLP-1R agonists on lung function in diabetic patients.
Aged
Bronchi
/ drug effects
Case-Control Studies
Diabetes Mellitus, Type 2
/ drug therapy
Drug Therapy, Combination
Female
Forced Expiratory Volume
/ drug effects
Glucagon-Like Peptide-1 Receptor
/ agonists
Humans
Hypoglycemic Agents
/ therapeutic use
Insulin
/ therapeutic use
Italy
/ epidemiology
Lung
/ physiopathology
Male
Maximal Expiratory Flow Rate
/ drug effects
Metformin
/ therapeutic use
Middle Aged
Prospective Studies
Respiratory Function Tests
/ methods
Vital Capacity
/ drug effects
Airway smooth muscle
Glucagon like Peptide-1 receptors
Lung function
Type 2 diabetes mellitus
Journal
Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438
Informations de publication
Date de publication:
Historique:
received:
16
04
2019
revised:
13
06
2019
accepted:
13
06
2019
pubmed:
23
6
2019
medline:
5
8
2020
entrez:
23
6
2019
Statut:
ppublish
Résumé
Preclinical research suggests a role of Glucagon Like Peptide-1 Receptors (GLP-1R) on the regulation of human bronchial tone. We investigated the effect of GLP-1R agonists on lung function of Type 2 Diabetes Mellitus (T2DM) population without co-existing chronic obstructive respiratory disorders. This was a prospective cohort study that examined change in lung function measurements over two years of T2DM patients (n = 32) treated with metformin monotherapy (control cohort), metformin plus GLP-1R agonists (GLP-1R agonists cohort), or metformin plus insulin (insulin cohort). After 24 months of treatment, the forced expiratory volume in 1 s (FEV Our preliminary results suggest a potential new therapeutic perspective to treat airway disorders with GLP-1R agonists.
Identifiants
pubmed: 31228775
pii: S0954-6111(19)30205-7
doi: 10.1016/j.rmed.2019.06.015
pii:
doi:
Substances chimiques
Glucagon-Like Peptide-1 Receptor
0
Hypoglycemic Agents
0
Insulin
0
Metformin
9100L32L2N
Types de publication
Clinical Trial
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-92Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.