Long-term excess risk of breast cancer after a single breast density measurement.
Breast
/ pathology
Breast Density
Breast Neoplasms
/ diagnosis
Carcinoma, Ductal, Breast
/ diagnosis
Carcinoma, Intraductal, Noninfiltrating
/ diagnosis
Case-Control Studies
Early Detection of Cancer
/ methods
Female
Follow-Up Studies
Humans
Mammography
/ methods
Middle Aged
Neoplasm Invasiveness
Prognosis
Risk Factors
Time Factors
Breast cancer
Breast density
Excess risk
Mammography
Screening
Journal
European journal of cancer (Oxford, England : 1990)
ISSN: 1879-0852
Titre abrégé: Eur J Cancer
Pays: England
ID NLM: 9005373
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
12
03
2019
revised:
02
05
2019
accepted:
03
05
2019
pubmed:
24
6
2019
medline:
29
5
2020
entrez:
24
6
2019
Statut:
ppublish
Résumé
Breast density is a risk factor for breast cancer. As density changes across a woman's life span, we studied for how long a single density measurement taken in (post-)menopausal women remains informative. We used data from Singaporean women who underwent a single mammography screen at age 50-64 years. For each case with breast cancer diagnosed at screening or in the subsequent 10 years, whether screen detected or diagnosed following symptoms, two age-matched controls were selected. We studied the excess risk of breast cancer, calculated as an odds ratio (OR) with conditional logistic regression and adjusted for body mass index, associated with 26-50% and with 51-100% density compared with ≤25% density by time since screening. In total, 490 women had breast cancer, of which 361 were diagnosed because of symptoms after screening. Women with 51-100% breast density had an excess risk of breast cancer that did not seem to attenuate with time. In 1-3 years after screening, the OR was 2.22 (95% confidence interval [CI]: 1.07-4.61); in 4-6 years after screening, the OR was 4.09 (95% CI: 2.21-7.58), and in 7-10 years after screening, the OR was 5.35 (95% CI: 2.57-11.15). Excess risk with a stable OR of about 2 was also observed for women with 26-50% breast density. These patterns were robust when the analyses were limited to post-menopausal women, non-users of hormonal replacement therapy and after stratification by age at density measurement. A single breast density measurement identifies women with an excess risk of breast cancer during at least the subsequent 10 years.
Identifiants
pubmed: 31229948
pii: S0959-8049(19)30312-0
doi: 10.1016/j.ejca.2019.05.009
pmc: PMC6658627
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-47Subventions
Organisme : Cancer Research UK
ID : C8162/A16892
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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