Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns.

Adult Cohort Studies DNA Methylation / genetics DNA-Binding Proteins / genetics Epigenesis, Genetic Female Fetal Blood Genome-Wide Association Study Gestational Age Humans Hypertension, Pregnancy-Induced / diagnosis Infant, Newborn Infant, Premature Pregnancy Pregnancy Outcome
DNA methylation cardiovascular diseases gestational age hypertension preeclampsia

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
08 2019
Historique:
pubmed: 25 6 2019
medline: 19 11 2019
entrez: 25 6 2019
Statut: ppublish

Résumé

Hypertensive disorders of pregnancy (HDP) are associated with low birth weight, shorter gestational age, and increased risk of maternal and offspring cardiovascular diseases later in life. The mechanisms involved are poorly understood, but epigenetic regulation of gene expression may play a part. We performed meta-analyses in the Pregnancy and Childhood Epigenetics Consortium to test the association between either maternal HDP (10 cohorts; n=5242 [cases=476]) or preeclampsia (3 cohorts; n=2219 [cases=135]) and epigenome-wide DNA methylation in cord blood using the Illumina HumanMethylation450 BeadChip. In models adjusted for confounders, and with Bonferroni correction, HDP and preeclampsia were associated with DNA methylation at 43 and 26 CpG sites, respectively. HDP was associated with higher methylation at 27 (63%) of the 43 sites, and across all 43 sites, the mean absolute difference in methylation was between 0.6% and 2.6%. Epigenome-wide associations of HDP with offspring DNA methylation were modestly consistent with the equivalent epigenome-wide associations of preeclampsia with offspring DNA methylation (R

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.119.12634 PMID: 31230546 PMC: PMC6635125
pubmed: 31230546
doi: 10.1161/HYPERTENSIONAHA.119.12634
pmc: PMC6635125
doi:

Substances chimiques

DNA-Binding Proteins 0

Types de publication

Journal Article Meta-Analysis Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

375-383

Subventions

Organisme : Medical Research Council
ID : MC_UU_00011/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/6
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK103246
Pays : United States
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI091905
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12013/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S003886/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : R01 ES022934
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States

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Auteurs

Nabila Kazmi (N)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Population Health Sciences, Bristol Medical School (N.K., G.C.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.

Gemma C Sharp (GC)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Population Health Sciences, Bristol Medical School (N.K., G.C.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
School of Oral and Dental Sciences (G.C.S.), University of Bristol, United Kingdom.

Sarah E Reese (SE)

Division of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC (S.E.R., Q.E.H., S.Z., S.J.L.).

Florianne O Vehmeijer (FO)

The Generation R Study Group (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Department of Epidemiology (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Department of Pediatrics (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.

Jari Lahti (J)

Department of Psychology and Logopedics, Faculty of Medicine (J.L., K.R.), University of Helsinki, Finland.
Helsinki Collegium of Advanced Studies (J.L.), University of Helsinki, Finland.

Christian M Page (CM)

Division of Mental and Physical Health (C.M.P., W.N.), Norwegian Institute of Public Health, Oslo.
Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Norway (C.M.P.).

Weiming Zhang (W)

Department of Biostatistics and Informatics (W.Z., K.J.K.), University of Colorado Anschutz Medical Campus, Aurora.

Sheryl L Rifas-Shiman (SL)

Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA (S.L.R.-S., E.O., M.-F.H.).

Faisal I Rezwan (FI)

Human Development and Health (F.I.R., J.W.H.), Faculty of Medicine University of Southampton, United Kingdom.

Andrew J Simpkin (AJ)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Insight Centre for Data Analytics, National University of Ireland, Galway (A.J.S.).

Kimberley Burrows (K)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Population Health Sciences, Bristol Medical School (N.K., G.C.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.

Tom G Richardson (TG)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Population Health Sciences, Bristol Medical School (N.K., G.C.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.

Diana L Santos Ferreira (DL)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Population Health Sciences, Bristol Medical School (N.K., G.C.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.

Abigail Fraser (A)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Population Health Sciences, Bristol Medical School (N.K., G.C.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.

Quaker E Harmon (QE)

Division of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC (S.E.R., Q.E.H., S.Z., S.J.L.).

Shanshan Zhao (S)

Division of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC (S.E.R., Q.E.H., S.Z., S.J.L.).

Vincent W V Jaddoe (VWV)

The Generation R Study Group (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Department of Epidemiology (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Department of Pediatrics (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.

Darina Czamara (D)

Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, Germany (D.C., E.B.B.).

Elisabeth B Binder (EB)

Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, Germany (D.C., E.B.B.).
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (E.B.B.).

Maria C Magnus (MC)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Population Health Sciences, Bristol Medical School (N.K., G.C.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Centre for Fertility and Health (M.C.M., S.E.H.), Norwegian Institute of Public Health, Oslo.

Siri E Håberg (SE)

Centre for Fertility and Health (M.C.M., S.E.H.), Norwegian Institute of Public Health, Oslo.

Wenche Nystad (W)

Division of Mental and Physical Health (C.M.P., W.N.), Norwegian Institute of Public Health, Oslo.

Ellen A Nohr (EA)

Research Unit of Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense (E.A.N.).

Anne P Starling (AP)

Department of Epidemiology (A.P.S., I.V.Y., D.D.), University of Colorado Anschutz Medical Campus, Aurora.

Katerina J Kechris (KJ)

Department of Biostatistics and Informatics (W.Z., K.J.K.), University of Colorado Anschutz Medical Campus, Aurora.

Ivana V Yang (IV)

Department of Epidemiology (A.P.S., I.V.Y., D.D.), University of Colorado Anschutz Medical Campus, Aurora.
Department of Medicine (I.V.Y.), University of Colorado Anschutz Medical Campus, Aurora.
Center for Genes, Environment and Health, National Jewish Health, Denver, CO (I.V.Y.).

Dawn L DeMeo (DL)

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.L.D.).

Augusto A Litonjua (AA)

Division of Pediatric Pulmonary Medicine, University of Rochester Medical Center, NY (A.A.L.).

Andrea Baccarelli (A)

Laboratory of Precision Environmental Biosciences, Columbia University Mailman School of Public Health, New York, NY (A.B.).

Emily Oken (E)

Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA (S.L.R.-S., E.O., M.-F.H.).

John W Holloway (JW)

Human Development and Health (F.I.R., J.W.H.), Faculty of Medicine University of Southampton, United Kingdom.
Clinical and Experimental Sciences (J.W.H., S.H.A.), Faculty of Medicine University of Southampton, United Kingdom.

Wilfried Karmaus (W)

Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, TN (W.K.).

Syed H Arshad (SH)

Clinical and Experimental Sciences (J.W.H., S.H.A.), Faculty of Medicine University of Southampton, United Kingdom.

Dana Dabelea (D)

Department of Epidemiology (A.P.S., I.V.Y., D.D.), University of Colorado Anschutz Medical Campus, Aurora.
Department of Pediatrics (D.D.), University of Colorado Anschutz Medical Campus, Aurora.

Thorkild I A Sørensen (TIA)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Novo Nordisk Foundation Center for Basic Metabolic Research, Section on Metabolic Genetics (T.I.A.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Department of Public Health, Section on Epidemiology (T.I.A.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Hannele Laivuori (H)

Institute for Molecular Medicine Finland, Helsinki Institute of Life Science (H.L.), University of Helsinki, Finland.
Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Finland (H.L.).
Faculty of Medicine and Life Sciences, University of Tampere, Finland (H.L.).
Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland (H.L.).
Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki. Finland (H.L.).

Katri Raikkonen (K)

Department of Psychology and Logopedics, Faculty of Medicine (J.L., K.R.), University of Helsinki, Finland.

Janine F Felix (JF)

The Generation R Study Group (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Department of Epidemiology (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Department of Pediatrics (F.O.V., V.W.V.J., J.F.F.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.

Stephanie J London (SJ)

Division of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC (S.E.R., Q.E.H., S.Z., S.J.L.).

Marie-France Hivert (MF)

Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA (S.L.R.-S., E.O., M.-F.H.).
Diabetes Unit, Massachusetts General Hospital, Boston, MA (M.-F.H.).

Tom R Gaunt (TR)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Population Health Sciences, Bristol Medical School (N.K., G.C.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
NIHR Bristol Biomedical Research Centre, Bristol, United Kingdom (T.R.G., D.A.L., C.L.R.).

Debbie A Lawlor (DA)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Population Health Sciences, Bristol Medical School (N.K., G.C.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
NIHR Bristol Biomedical Research Centre, Bristol, United Kingdom (T.R.G., D.A.L., C.L.R.).

Caroline L Relton (CL)

From the MRC Integrative Epidemiology Unit (N.K., G.C.S., A.J.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.I.A.S., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
Population Health Sciences, Bristol Medical School (N.K., G.C.S., K.B., T.G.R., D.L.S.F., A.F., M.C.M., T.R.G., D.A.L., C.L.R.), University of Bristol, United Kingdom.
NIHR Bristol Biomedical Research Centre, Bristol, United Kingdom (T.R.G., D.A.L., C.L.R.).

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Structures de l'embryon › Foetus › Sang foetal › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Âge gestationnel › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Hypertension artérielle gravidique › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Prématuré › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Hypertensive Disorders of Pregnancy and DNA...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Issue de la grossesse › Hypertensive Disorders of Pregnancy and DNA...