Mesenchymal Stromal Cells for Transplant Tolerance.
Adaptive Immunity
Animals
B-Lymphocytes
/ immunology
Cell Compartmentation
/ immunology
Cellular Microenvironment
/ immunology
Graft Rejection
/ immunology
Humans
Immune Tolerance
Immunity, Innate
Immunosuppression Therapy
/ methods
Immunosuppressive Agents
/ therapeutic use
Macrophages
/ immunology
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
/ metabolism
Organ Transplantation
T-Lymphocytes
/ immunology
Time Factors
Transplantation Tolerance
B cells
T cells
macrophage
mesenchymal (stromal) stem cells
tolerance
transplantation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
21
03
2019
accepted:
21
05
2019
entrez:
25
6
2019
pubmed:
25
6
2019
medline:
29
10
2020
Statut:
epublish
Résumé
In solid organ transplantation lifelong immunosuppression exposes transplant recipients to life-threatening complications, such as infections and malignancies, and to severe side effects. Cellular therapy with mesenchymal stromal cells (MSC) has recently emerged as a promising strategy to regulate anti-donor immune responses, allowing immunosuppressive drug minimization and tolerance induction. In this review we summarize preclinical data on MSC in solid organ transplant models, focusing on potential mechanisms of action of MSC, including down-regulation of effector T-cell response and activation of regulatory pathways. We will also provide an overview of available data on safety and feasibility of MSC therapy in solid organ transplant patients, highlighting the issues that still need to be addressed before establishing MSC as a safe and effective tolerogenic cell therapy in transplantation.
Identifiants
pubmed: 31231393
doi: 10.3389/fimmu.2019.01287
pmc: PMC6559333
doi:
Substances chimiques
Immunosuppressive Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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