Lactational High-Fat Diet Exposure Programs Metabolic Inflammation and Bone Marrow Adiposity in Male Offspring.
Adipose Tissue
/ metabolism
Adiposity
Age Factors
Animals
Biomarkers
/ blood
Blood Glucose
/ metabolism
Bone Marrow
/ metabolism
Diet, High-Fat
/ adverse effects
Female
Hyperglycemia
/ blood
Inflammation
/ blood
Inflammation Mediators
/ blood
Insulin Resistance
Lactation
Male
Maternal Exposure
/ adverse effects
Maternal Nutritional Physiological Phenomena
Mice, Inbred C57BL
Myeloid Cells
/ metabolism
Nutritional Status
Obesity
/ blood
Risk Factors
Sex Factors
Time Factors
Weight Gain
adipose tissue
developmental programming
inflammation
lactation
metabolism
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
21 Jun 2019
21 Jun 2019
Historique:
received:
30
04
2019
revised:
01
06
2019
accepted:
18
06
2019
entrez:
26
6
2019
pubmed:
27
6
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Overnutrition during critical windows of development plays a significant role in life-long metabolic disease risk. Early exposure to excessive nutrition may result in altered programming leading to increased susceptibility to obesity, inflammation, and metabolic complications. This study investigated the programming effects of high-fat diet (HFD) exposure during the lactation period on offspring adiposity and inflammation. Female C57Bl/6J dams were fed a normal diet or a 60% HFD during lactation. Offspring were weaned onto a normal diet until 12 weeks of age when half were re-challenged with HFD for 12 weeks. Metabolic testing was performed throughout adulthood. At 24 weeks, adipose depots were isolated and evaluated for macrophage profiling and inflammatory gene expression. Males exposed to HFD during lactation had insulin resistance and glucose intolerance as adults. After re-introduction to HFD, males had increased weight gain and worsened insulin resistance and hyperglycemia. There was increased infiltration of pro-inflammatory CD11c
Identifiants
pubmed: 31234301
pii: nu11061393
doi: 10.3390/nu11061393
pmc: PMC6628038
pii:
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Inflammation Mediators
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : T32DK071212
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK102526
Pays : United States
Organisme : NIDDK NIH HHS
ID : R24 DK084970
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08DK102526
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115583
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK089503
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01DK115583
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK101755
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK062876
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08DK101755
Pays : United States
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