Axonal pathology in hPSC-based models of Parkinson's disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus.
Animals
Antioxidant Response Elements
/ genetics
Axons
/ drug effects
Cell Differentiation
/ genetics
Dopaminergic Neurons
/ metabolism
Enhancer Elements, Genetic
Humans
Microtubule-Associated Proteins
/ genetics
Mitochondria
/ metabolism
Mutation
NF-E2-Related Factor 2
/ genetics
Neurites
/ metabolism
Parkinson Disease
/ drug therapy
Pluripotent Stem Cells
/ metabolism
Protein Kinase C
/ genetics
Substantia Nigra
/ metabolism
alpha-Synuclein
/ genetics
Map1b
Nrf2
Parkinson’s disease
human pluripotent stem cells
α-synuclein
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
09 07 2019
09 07 2019
Historique:
pubmed:
27
6
2019
medline:
31
3
2020
entrez:
26
6
2019
Statut:
ppublish
Résumé
While mutations in the
Identifiants
pubmed: 31235589
pii: 1900576116
doi: 10.1073/pnas.1900576116
pmc: PMC6628831
doi:
Substances chimiques
Microtubule-Associated Proteins
0
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
SNCA protein, human
0
alpha-Synuclein
0
microtubule-associated protein 1B
0
Protein Kinase C
EC 2.7.11.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14280-14289Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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