Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism.

Animals Athletes Exercise Gastrointestinal Microbiome Humans Lactic Acid / metabolism Metagenomics Mice Mice, Inbred C57BL Propionates / metabolism Running Veillonella / metabolism

Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
07 2019
Historique:
received: 21 05 2018
accepted: 10 05 2019
pubmed: 27 6 2019
medline: 15 11 2019
entrez: 26 6 2019
Statut: ppublish

Résumé

The human gut microbiome is linked to many states of human health and disease

Identifiants

DOI: 10.1038/s41591-019-0485-4 PMID: 31235964 PMC: PMC7368972
pubmed: 31235964
doi: 10.1038/s41591-019-0485-4
pii: 10.1038/s41591-019-0485-4
pmc: PMC7368972
mid: NIHMS1529145
doi:

Substances chimiques

Propionates 0
Lactic Acid 33X04XA5AT

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1104-1109

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK040561
Pays : United States
Organisme : NLM NIH HHS
ID : T15 LM007092
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG002295
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007260
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK036836
Pays : United States

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Jonathan Scheiman (J)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Fitbiomics, New York, NY, USA.

Jacob M Luber (JM)

Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.
Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0001-5268-5732

Theodore A Chavkin (TA)

Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.
Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.

Tara MacDonald (T)

Section on Clinical, Behavioral and Outcomes Research, Joslin Diabetes Center, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.

Angela Tung (A)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
ORCID: 0000-0003-3612-2934

Loc-Duyen Pham (LD)

Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.
Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.

Marsha C Wibowo (MC)

Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.
Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.

Renee C Wurth (RC)

Fitbiomics, New York, NY, USA.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Sukanya Punthambaker (S)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

Braden T Tierney (BT)

Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.
Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.

Zhen Yang (Z)

Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.
Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Department of Combinatorics and Optimization, University of Waterloo, Waterloo, Ontario, Canada.

Mohammad W Hattab (MW)

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

Julian Avila-Pacheco (J)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Clary B Clish (CB)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0001-8259-9245

Sarah Lessard (S)

Section on Clinical, Behavioral and Outcomes Research, Joslin Diabetes Center, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.

George M Church (GM)

Department of Genetics, Harvard Medical School, Boston, MA, USA. gc@hms.harvard.edu.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. gc@hms.harvard.edu.

Aleksandar D Kostic (AD)

Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA. aleksandar.kostic@joslin.harvard.edu.
Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA. aleksandar.kostic@joslin.harvard.edu.
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA. aleksandar.kostic@joslin.harvard.edu.
ORCID: 0000-0002-0837-4360

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Meta-omics analysis of elite athletes...
questionsmedicales.fr › Personnes › Athlètes › Meta-omics analysis of elite athletes...
questionsmedicales.fr › Activités humaines › Exercice physique › Meta-omics analysis of elite athletes...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Meta-omics analysis of elite athletes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Meta-omics analysis of elite athletes...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › Acide lactique › Meta-omics analysis of elite athletes...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Métagénomique › Meta-omics analysis of elite athletes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Meta-omics analysis of elite athletes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Meta-omics analysis of elite athletes...
questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Propionates › Meta-omics analysis of elite athletes...
questionsmedicales.fr › Activités humaines › Activités de loisirs › Loisir › Sports › Course à pied › Meta-omics analysis of elite athletes...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Bactéries anaérobies à Gram négatif › Bâtonnets à Gram négatif anaérobies droits, incurvés et spiralés › Veillonellaceae › Veillonella › Meta-omics analysis of elite athletes...