Effect of tranexamic acid in improving the lifespan of naturally aging mice.
Interleukin-6
Matrix metalloproteinase-9
Natural aging
Reactive oxygen species
Tranexamic acid
Tumor necrosis factor-α
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
20
05
2019
accepted:
18
06
2019
pubmed:
27
6
2019
medline:
22
4
2020
entrez:
26
6
2019
Statut:
ppublish
Résumé
An effective method to improve lifespan is not known. Therefore, in this study, we examined the lifespan-extending effect of tranexamic acid in normal mice. We bred hairless mice without exposure to ultraviolet radiation and psychical stress until they died naturally. During the study period, the mice were orally administered tranexamic acid (12 mg/kg/day) three times weekly. An increase in the lifespan of mice was observed by tranexamic acid administration. Furthermore, age-related diseases of the skin were ameliorated by tranexamic acid administration. Moreover, the blood level of tumor necrosis factor-α, interleukin-6, reactive oxygen species (ROS), and matrix metalloproteinase (MMP)-9 was decreased by tranexamic acid administration. These results indicate that tranexamic acid suppresses the secretion of inflammatory cytokines, MMP-9, and ROS induced by natural aging, ameliorating age-related diseases, and, consequently, extending the lifespan.
Identifiants
pubmed: 31236768
doi: 10.1007/s10787-019-00616-2
pii: 10.1007/s10787-019-00616-2
doi:
Substances chimiques
Interleukin-6
0
Reactive Oxygen Species
0
Tumor Necrosis Factor-alpha
0
Tranexamic Acid
6T84R30KC1
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1319-1323Subventions
Organisme : JSPS KAKENHI
ID : Grant Number 18K11085
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