Stages of pregnancy and weaning influence the gut microbiota diversity and function in sows.
gut microbiota
metabolite
microbial diversity
sows
stages of pregnancy
Journal
Journal of applied microbiology
ISSN: 1365-2672
Titre abrégé: J Appl Microbiol
Pays: England
ID NLM: 9706280
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
11
03
2019
revised:
07
05
2019
accepted:
14
05
2019
pubmed:
27
6
2019
medline:
31
10
2019
entrez:
26
6
2019
Statut:
ppublish
Résumé
The gut microbiota is believed to play important roles in the health of pregnant mammals, including their nutrient metabolism, immune programming and metabolic regulation. However, until recently, the shifts in gut microbiota composition and faecal and blood metabolic activity during different stages of pregnancy had not been investigated. We investigated the shifts in backfat thickness, plasma and faecal metabolites and gut microbiota on days 30, 60, 90 and 110 of pregnancy and on day 21 after parturition (weaning) in sows. The backfat thickness of sows did not significantly differ among the different stages of pregnancy. The plasma concentrations of lipid metabolites, including triacylglycerol (TG), total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol and calcium were reduced (P < 0·05) during pregnancy. In addition, the concentration of these metabolites, except TG, reached their maximum at the time of weaning. We also found that Tenericutes, Fibrobacteres and Cyanobacteria varied significantly according to the stages of pregnancy in sows (P < 0·05). Most of the genera, such as Clostridiales, Desulfovibrio, Mogibacteriaceae and Prevotella, increased (P < 0·05) with the progression of pregnancy and decreased (P < 0·05) at weaning. The alpha diversity values (i.e., Shannon diversity and observed species) of sow gut microbiota increased (P < 0·05) from pregnancy to weaning. Pregnancy stages also significantly influenced (P < 0·05) the community structure (beta diversity) of gut microbiota. The progression of pregnancy was associated with changes in lipid metabolism and several carbohydrate-degradation bacteria (i.e., Prevotella, Succinivibrio, Bacteroides and Parabacteroides). Although causal links between the measured parameters remain hypothetical, these findings suggest that the increased diversity and concentration of beneficial gut microbes are associated with the metabolism of pregnant sows. Manipulation of the sow gut microbiota composition may potentially influence metabolism and health during pregnancy.
Identifiants
pubmed: 31237071
doi: 10.1111/jam.14344
pmc: PMC6852164
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
867-879Subventions
Organisme : National Key R&D Program
ID : 2017YFD0500503
Organisme : National Nature Science Foundation of China
ID : 31572421
Organisme : National Nature Science Foundation of China
ID : 31772613
Organisme : Chinese Academy of Sciences
ID : KFZD-SW-219-2-3
Informations de copyright
© 2019 The Authors. Journal of Applied Microbiology published by John Wiley & Sons Ltd on behalf of The Society for Applied Microbiology.
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