Correlation between MDSC and Immune Tolerance in Transplantation: Cytokines, Pathways and Cell-cell Interaction.

Cell Communication / genetics Graft Survival / genetics Granulocyte-Macrophage Colony-Stimulating Factor / genetics Humans Immune Tolerance / genetics Immunosuppression Therapy / trends Interleukin-6 / genetics Janus Kinases / genetics Myeloid-Derived Suppressor Cells / metabolism Nitric Oxide Synthase Type II / genetics Receptors, Interleukin-8B / genetics STAT Transcription Factors / genetics
CXCR2 GM-CSF JAK/STAT Myeloid-derived suppressor cells immune tolerance transplantation.

Journal

Current gene therapy
ISSN: 1875-5631
Titre abrégé: Curr Gene Ther
Pays: United Arab Emirates
ID NLM: 101125446

Informations de publication

Date de publication:
2019
Historique:
received: 27 02 2019
revised: 06 05 2019
accepted: 24 05 2019
pubmed: 27 6 2019
medline: 7 7 2020
entrez: 26 6 2019
Statut: ppublish

Résumé

MDSCs play an important role in the induction of immune tolerance. Cytokines and chemokines (GM-CSF, IL-6) contributed to the expansion, accumulation of MDSCs, and MDSCs function through iNOS, arginase and PD-L1. MDSCs are recruited and regulated through JAK/STAT, mTOR and Raf/MEK/ERK signaling pathways. MDSCs' immunosuppressive functions were realized through Tregs-mediated pathways and their direct suppression of immune cells. All of the above contribute to the MDSC-related immune tolerance in transplantation. MDSCs have huge potential in prolonging graft survival and reducing rejection through different ways and many other factors worthy to be further investigated are also introduced.

Identifiants

DOI: 10.2174/1566523219666190618093707 PMID: 31237207
pubmed: 31237207
pii: CGT-EPUB-98913
doi: 10.2174/1566523219666190618093707
doi:

Substances chimiques

CXCR2 protein, human 0
Interleukin-6 0
Receptors, Interleukin-8B 0
STAT Transcription Factors 0
Granulocyte-Macrophage Colony-Stimulating Factor 83869-56-1
Nitric Oxide Synthase Type II EC 1.14.13.39
Janus Kinases EC 2.7.10.2

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

81-92

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Auteurs

Tianying Yang (T)

Department of Urology, ZhongShan Hospital, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.

Jiawei Li (J)

Department of Urology, ZhongShan Hospital, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.

Ruimin Li (R)

Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.
Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China.

Chunchen Yang (C)

Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai, China.

Weitao Zhang (W)

Department of Urology, ZhongShan Hospital, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.

Yue Qiu (Y)

Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Cheng Yang (C)

Department of Urology, ZhongShan Hospital, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.

Ruiming Rong (R)

Department of Urology, ZhongShan Hospital, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.
Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai, China.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Communication cellulaire › Correlation between MDSC and Immune Tolerance...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Survie du greffon › Correlation between MDSC and Immune Tolerance...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de croissance hématopoïétique › Facteurs de stimulation des colonies › Facteur de stimulation des colonies de granulocytes et de macrophages › Correlation between MDSC and Immune Tolerance...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Correlation between MDSC and Immune Tolerance...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Correlation between MDSC and Immune Tolerance...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Correlation between MDSC and Immune Tolerance...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Correlation between MDSC and Immune Tolerance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Janus kinases › Correlation between MDSC and Immune Tolerance...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Cellules myéloïdes suppressives › Correlation between MDSC and Immune Tolerance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Nitric oxide synthase type II › Correlation between MDSC and Immune Tolerance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-8 › Récepteurs à l'interleukine-8B › Correlation between MDSC and Immune Tolerance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Correlation between MDSC and Immune Tolerance...