Controversial roles for dexamethasone in glioblastoma - Opportunities for novel vascular targeting therapies.
Angiopoietin/Tie2
Glioblastoma
anti-vascular endothelial growth factor
blood-brain barrier
cerebral edema
dexamethasone
vascular endothelial protein tyrosine phosphatase
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
pubmed:
27
6
2019
medline:
10
5
2020
entrez:
27
6
2019
Statut:
ppublish
Résumé
Glioblastoma is a highly aggressive and treatment resistant primary brain tumor. Features of glioblastoma include peritumoral cerebral edema, the major contributor to neurological impairment. Although the current clinical approach to edema management is administration of the synthetic corticoid dexamethasone, increasing evidence indicates numerous adverse effects of dexamethasone on glioblastoma burden at the molecular, cellular and clinical level. The contradictions of dexamethasone for glioblastoma and brain metastasis therapy are discussed in this article. Finally, alternative strategies for cerebrovascular edema therapy with vascular stabilizing, anti-permeability agents that are either approved or in clinical trials for diabetic retinopathy and macula edema, are addressed.
Identifiants
pubmed: 31238763
doi: 10.1177/0271678X19859847
pmc: PMC6681527
doi:
Substances chimiques
Glucocorticoids
0
Dexamethasone
7S5I7G3JQL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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