Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic
Adolescent
Animals
Anti-Bacterial Agents
/ pharmacology
Antimicrobial Cationic Peptides
/ genetics
Child
Child, Preschool
Escherichia coli Infections
/ enzymology
Female
Gene Silencing
Humans
Immunity, Innate
Infant
Kidney
/ enzymology
Male
Mice
Mice, Transgenic
Phenotype
Prognosis
Ribonucleases
/ genetics
Urinary Bladder
/ enzymology
Urinary Tract Infections
/ enzymology
Uropathogenic Escherichia coli
Urothelium
/ metabolism
Young Adult
antimicrobial peptides
intercalated cells
ribonuclease 7
urinary tract infection
urothelium
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
14
09
2018
accepted:
17
04
2019
pubmed:
27
6
2019
medline:
28
4
2020
entrez:
27
6
2019
Statut:
ppublish
Résumé
Evidence suggests that antimicrobial peptides, components of the innate immune response, protect the kidneys and bladder from bacterial challenge. We previously identified ribonuclease 7 (RNase 7) as a human antimicrobial peptide that has bactericidal activity against uropathogenic To investigate RNase 7's role in preventing urinary tract infection (UTI), we quantified urinary RNase 7 concentrations in 29 girls and adolescents with a UTI history and 29 healthy female human controls. To assess RNase 7's antimicrobial activity Compared with controls, study participants with a UTI history had 1.5-fold lower urinary RNase 7 concentrations. When RNase 7 was silenced These findings provide evidence that RNase 7 has a role in kidney and bladder host defense against UPEC and establish a foundation for investigating RNase 7 as a UTI prognostic marker or nonantibiotic-based therapy.
Sections du résumé
BACKGROUND
Evidence suggests that antimicrobial peptides, components of the innate immune response, protect the kidneys and bladder from bacterial challenge. We previously identified ribonuclease 7 (RNase 7) as a human antimicrobial peptide that has bactericidal activity against uropathogenic
METHODS
To investigate RNase 7's role in preventing urinary tract infection (UTI), we quantified urinary RNase 7 concentrations in 29 girls and adolescents with a UTI history and 29 healthy female human controls. To assess RNase 7's antimicrobial activity
RESULTS
Compared with controls, study participants with a UTI history had 1.5-fold lower urinary RNase 7 concentrations. When RNase 7 was silenced
CONCLUSIONS
These findings provide evidence that RNase 7 has a role in kidney and bladder host defense against UPEC and establish a foundation for investigating RNase 7 as a UTI prognostic marker or nonantibiotic-based therapy.
Identifiants
pubmed: 31239387
pii: ASN.2018090929
doi: 10.1681/ASN.2018090929
pmc: PMC6683711
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antimicrobial Cationic Peptides
0
Ribonucleases
EC 3.1.-
Ribonuclease 7
EC 3.1.27.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1385-1397Subventions
Organisme : NCI NIH HHS
ID : P30 CA016058
Pays : United States
Organisme : NIDDK NIH HHS
ID : R03 DK109242
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114035
Pays : United States
Organisme : NIDDK NIH HHS
ID : R03 DK118306
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK102594
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115737
Pays : United States
Informations de copyright
Copyright © 2019 by the American Society of Nephrology.
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