Delivery of Rapamycin Using In Situ Forming Implants Promotes Immunoregulation and Vascularized Composite Allograft Survival.
Animals
Composite Tissue Allografts
/ drug effects
Drug Delivery Systems
Graft Rejection
/ prevention & control
Graft Survival
/ drug effects
Hindlimb
/ transplantation
Immunosuppressive Agents
/ pharmacology
Male
Rats
Rats, Inbred Lew
Sirolimus
/ pharmacology
T-Lymphocytes, Regulatory
/ immunology
Transplantation Chimera
Transplantation Tolerance
/ immunology
Vascularized Composite Allotransplantation
/ adverse effects
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
25 06 2019
25 06 2019
Historique:
received:
13
06
2018
accepted:
13
06
2019
entrez:
27
6
2019
pubmed:
27
6
2019
medline:
28
10
2020
Statut:
epublish
Résumé
Vascularized composite allotransplantation (VCA), such as hand and face transplantation, is emerging as a potential solution in patients that suffered severe injuries. However, adverse effects of chronic high-dose immunosuppression regimens strongly limit the access to these procedures. In this study, we developed an in situ forming implant (ISFI) loaded with rapamycin to promote VCA acceptance. We hypothesized that the sustained delivery of low-dose rapamycin in proximity to the graft may promote graft survival and induce an immunoregulatory microenvironment, boosting the expansion of T regulatory cells (T
Identifiants
pubmed: 31239498
doi: 10.1038/s41598-019-45759-y
pii: 10.1038/s41598-019-45759-y
pmc: PMC6592945
doi:
Substances chimiques
Immunosuppressive Agents
0
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9269Références
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