Iterative synthetic strategies and gene deletant experiments enable the first identification of polysulfides in Saccharomyces cerevisiae.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
23 Jul 2019
23 Jul 2019
Historique:
pubmed:
27
6
2019
medline:
2
8
2019
entrez:
27
6
2019
Statut:
ppublish
Résumé
New evidence on the role of H2S as a gasotransmitter suggests that the true signalling effectors are polysulfides. Both oxidized polysulfides and hydropolysulfides were synthesized and their presence in S. cerevisiae was observed for the first time. A single gene-deletant approach allowed observation of the modulation of polysulfide species and levels.
Substances chimiques
Carrier Proteins
0
Gasotransmitters
0
Saccharomyces cerevisiae Proteins
0
Sulfides
0
Tum1 protein, S cerevisiae
0
polysulfide
9080-49-3
Cystathionine beta-Synthase
EC 4.2.1.22
CYS3 protein, S cerevisiae
EC 4.4.1.1
Cystathionine gamma-Lyase
EC 4.4.1.1
Types de publication
Journal Article
Langues
eng