Management of the toxicity of chemotherapy and targeted therapies in elderly cancer patients.
Cancer
Chemotherapy
Elderly
Support treatments
Toxicity
Journal
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
ISSN: 1699-3055
Titre abrégé: Clin Transl Oncol
Pays: Italy
ID NLM: 101247119
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
04
04
2019
accepted:
16
06
2019
pubmed:
27
6
2019
medline:
12
1
2021
entrez:
27
6
2019
Statut:
ppublish
Résumé
The elderly form a very heterogeneous group in relation to their general health state, degree of dependence, comorbidities, performance status, physical reserve and geriatric situation, so cancer treatment in the older patient remains a therapeutic challenge. The physiological changes associated with aging increase the risk of developing a serious toxicity induced by chemotherapy treatment, as well as other undesirable consequences as hospitalizations, dependence and non-compliance with treatment, that can negatively affect survival, quality of life and treatment efficacy. The use of hematopoietic growth factors and other active supportive interventions in the elderly can help prevent and/or alleviate these toxicities. However, we have little data on the efficacy and tolerance of support treatments in the older patient. The objective of this work is to review the most frequent toxicities of oncological treatments in the elderly and their management.
Identifiants
pubmed: 31240462
doi: 10.1007/s12094-019-02167-y
pii: 10.1007/s12094-019-02167-y
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
457-467Références
Clin Geriatr Med. 2016 Feb;32(1):63-80
pubmed: 26614861
J Geriatr Oncol. 2013 Jan;4(1):78-83
pubmed: 24071495
Cancer. 2014 May 15;120(10):1453-61
pubmed: 24615748
Cancer. 2004 Jan 1;100(1):6-11
pubmed: 14692018
Immun Ageing. 2008 Dec 30;5:16
pubmed: 19116012
Eur J Cancer. 2006 Sep;42(14):2271-6
pubmed: 16644208
Future Oncol. 2016 Feb;12(3):373-87
pubmed: 26584409
Support Care Cancer. 2013 Jul;21(7):2059-66
pubmed: 23446880
Oncologist. 2011;16(3):378-87
pubmed: 21349949
Lancet. 2009 May 2;373(9674):1532-42
pubmed: 19410717
J Geriatr Oncol. 2015 Jan;6(1):70-83
pubmed: 25454770
Clin Interv Aging. 2012;7:159-63
pubmed: 22791988
J Clin Oncol. 2008 Jan 1;26(1):54-9
pubmed: 18165640
Nephrol Dial Transplant. 2000;15 Suppl 3:14-8
pubmed: 11032352
Curr Oncol Rep. 2016 Aug;18(8):51
pubmed: 27342609
Arch Intern Med. 1996 Mar 25;156(6):645-52
pubmed: 8629876
Oncotarget. 2018 Jan 2;9(9):8253-8262
pubmed: 29492192
Ann Oncol. 2016 Sep;27(suppl 5):v111-v118
pubmed: 27664247
J Geriatr Oncol. 2015 Jul;6(4):272-9
pubmed: 26088748
Cancer Control. 2015 Oct;22(4):480-8
pubmed: 26678975
J Clin Oncol. 2005 Oct 1;23(28):6865-72
pubmed: 16192578
Curr Oncol. 2010 Oct;17(5):17-21
pubmed: 20975874
J Clin Oncol. 2014 Aug 20;32(24):2595-603
pubmed: 25071125
Breast Cancer Res Treat. 2011 Apr;126(2):529-37
pubmed: 20803066
Crit Rev Oncol Hematol. 2005 Sep;55(3):241-52
pubmed: 16084735
J Clin Oncol. 2007 Aug 20;25(24):3699-704
pubmed: 17704418
J Clin Oncol. 2014 Aug 20;32(24):2627-34
pubmed: 25071112
J Clin Oncol. 2004 Jul 15;22(14):2918-26
pubmed: 15254061
J Clin Oncol. 1997 Feb;15(2):833-9
pubmed: 9053511
Clin Colorectal Cancer. 2017 Dec;16(4):275-285
pubmed: 29066018
Eur J Cancer. 2016 Dec;69:199-215
pubmed: 27855351
J Natl Cancer Inst. 2013 Aug 21;105(16):1230-8
pubmed: 23853057
Semin Oncol Nurs. 2011 May;27(2):154-60
pubmed: 21514484
Support Care Cancer. 2012 Mar;20(3):583-9
pubmed: 21380613
Ann Oncol. 2011 Feb;22(2):257-67
pubmed: 20956616
J Clin Oncol. 2008 Feb 1;26(4):549-55
pubmed: 18071188
J Clin Oncol. 2010 Sep 20;28(27):4120-8
pubmed: 20585090
Ann Oncol. 2015 Feb;26(2):288-300
pubmed: 24936581
J Clin Oncol. 2013 Apr 10;31(11):1464-70
pubmed: 23460711
J Clin Oncol. 2014 Aug 20;32(24):2635-46
pubmed: 25071113
J Clin Oncol. 2002 Jan 15;20(2):494-502
pubmed: 11786579
Crit Rev Oncol Hematol. 2018 Nov;131:16-23
pubmed: 30293701
Am Soc Clin Oncol Educ Book. 2015;:e544-52
pubmed: 25993221
J Natl Cancer Inst. 2006 Aug 16;98(16):1108-17
pubmed: 16912263
J Womens Health (Larchmt). 2007 Jan-Feb;16(1):11-23
pubmed: 17324093
Crit Rev Oncol Hematol. 2011 Jun;78(3):227-42
pubmed: 20599391
N Engl J Med. 2012 Jul 5;367(1):40-9
pubmed: 22762317
Osteoporos Int. 2007 Aug;18(8):1033-46
pubmed: 17323110
N Engl J Med. 2004 Dec 16;351(25):2590-8
pubmed: 15602019
Eur J Cancer. 2003 Nov;39(16):2264-72
pubmed: 14556916
J Geriatr Oncol. 2019 Mar;10(2):202-209
pubmed: 30224184
J Clin Oncol. 2000 Aug;18(16):3038-51
pubmed: 10944139
Gerontology. 2010;56(3):303-9
pubmed: 19940466
J Geriatr Oncol. 2017 Mar;8(2):96-101
pubmed: 27856262
Ann Intern Med. 1993 Feb 1;118(3):219-23
pubmed: 8417639
Cancer. 2012 Jul 1;118(13):3377-86
pubmed: 22072065
Crit Rev Oncol Hematol. 2000 Feb;33(2):143-8
pubmed: 10737376
Oncologist. 2013;18(4):408-14
pubmed: 23576485
J Natl Cancer Inst. 2007 Aug 15;99(16):1232-9
pubmed: 17686822
Cancer. 2005 Oct 1;104(7):1520-30
pubmed: 16110508
J Support Oncol. 2003 Nov-Dec;1(4 Suppl 2):18-24
pubmed: 15346996
J Natl Compr Canc Netw. 2017 Sep;15(9):1111-1120
pubmed: 28874596
J Clin Oncol. 2017 Jun 10;35(17):1945-1951
pubmed: 28441110
BMC Cancer. 2017 Mar 27;17(1):218
pubmed: 28347291
J Geriatr Oncol. 2019 Jan;10(1):4-30
pubmed: 30017734
Lancet Oncol. 2014 Apr;15(4):436-44
pubmed: 24582505
J Clin Oncol. 2005 Oct 20;23(30):7685-96
pubmed: 16234530
Oncologist. 2008;13 Suppl 3:11-5
pubmed: 18458119
J Clin Oncol. 2014 Aug 20;32(24):2587-94
pubmed: 25071116
J Clin Oncol. 2007 May 10;25(14):1832-43
pubmed: 17488981
Ann Oncol. 2005 Nov;16(11):1795-800
pubmed: 16093275
Drugs. 2002;62 Suppl 1:47-63
pubmed: 12479594
Eur J Cancer. 2007 Oct;43(15):2203-10
pubmed: 17662595
Ann Oncol. 2015 Sep;26 Suppl 5:v139-51
pubmed: 26142468
N Engl J Med. 2005 Jan 13;352(2):154-64
pubmed: 15647578
Support Care Cancer. 2013 Aug;21(8):2137-43
pubmed: 23471537
Br J Cancer. 2018 May;118(9):1169-1175
pubmed: 29576622
J Am Coll Cardiol. 2009 Jun 16;53(24):2231-47
pubmed: 19520246
N Engl J Med. 2005 Sep 8;353(10):988-98
pubmed: 16148284
J Geriatr Oncol. 2017 Mar;8(2):86-95
pubmed: 27829539
J Clin Oncol. 2011 Sep 1;29(25):3457-65
pubmed: 21810685
J Clin Oncol. 2016 Jul 10;34(20):2366-71
pubmed: 27185838
Surg Oncol. 2010 Sep;19(3):117-23
pubmed: 20006489
J Clin Oncol. 2007 Sep 1;25(25):3808-15
pubmed: 17664460
J Geriatr Oncol. 2015 Mar;6(2):133-40
pubmed: 25666905
JAMA. 2008 Feb 27;299(8):914-24
pubmed: 18314434
JAMA. 2013 Apr 3;309(13):1359-67
pubmed: 23549581
J Clin Oncol. 2013 Sep 1;31(25):3076-82
pubmed: 23897970
J Thorac Oncol. 2011 Jan;6(1):115-20
pubmed: 21107287
J Natl Cancer Inst. 2009 Sep 2;101(17):1206-15
pubmed: 19638506
J Geriatr Oncol. 2014 Jan;5(1):57-64
pubmed: 24484719