A Zoonotic Adenoviral Human Pathogen Emerged through Genomic Recombination among Human and Nonhuman Simian Hosts.
Adenovirus Infections, Human
/ virology
Adenoviruses, Human
/ genetics
Adenoviruses, Simian
/ genetics
Animals
Computational Biology
/ methods
DNA, Viral
/ genetics
Evolution, Molecular
Genome, Viral
/ genetics
Genomics
/ methods
Humans
Pan paniscus
/ virology
Pan troglodytes
/ virology
Phylogeny
Recombination, Genetic
/ genetics
Zoonoses
adenovirus
anthroponosis
emerging pathogen
genomics
homologous recombination
virus evolution
zoonosis
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
15 09 2019
15 09 2019
Historique:
received:
03
04
2019
accepted:
18
06
2019
pubmed:
28
6
2019
medline:
8
7
2020
entrez:
28
6
2019
Statut:
epublish
Résumé
Genomics analysis of a historically intriguing and predicted emergent human adenovirus (HAdV) pathogen, which caused pneumonia and death, provides insight into a novel molecular evolution pathway involving "ping-pong" zoonosis and anthroponosis. The genome of this promiscuous pathogen is embedded with evidence of unprecedented multiple, multidirectional, stable, and reciprocal cross-species infections of hosts from three species (human, chimpanzee, and bonobo). This recombinant genome, typed as HAdV-B76, is identical to two recently reported simian AdV (SAdV) genomes isolated from chimpanzees and bonobos. Additionally, the presence of a critical adenoviral replication element found in HAdV genomes, in addition to genes that are highly similar to counterparts in other HAdVs, reinforces its potential as a human pathogen. Reservoirs in nonhuman hosts may explain periods of apparent absence and then reemergence of human adenoviral pathogens, as well as present pathways for the genesis of those thought to be newly emergent. The nature of the HAdV-D76 genome has implications for the use of SAdVs as gene delivery vectors in human gene therapy and vaccines, selected to avoid preexisting and potentially fatal host immune responses to HAdV.
Identifiants
pubmed: 31243128
pii: JVI.00564-19
doi: 10.1128/JVI.00564-19
pmc: PMC6714811
pii:
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : HHSN272200900007C
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103447
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY014104
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY013124
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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