Simultaneous Presentation of Lymphomatoid Granulomatosis and Multiple myeloma in an Immunodeficient Patient with Rheumatoid Arthritis.
Aged
Arthritis, Rheumatoid
/ complications
Biopsy
Brain Neoplasms
/ diagnosis
Fatal Outcome
Female
Humans
Immunologic Deficiency Syndromes
/ complications
Lung Neoplasms
/ diagnosis
Lymphomatoid Granulomatosis
/ diagnosis
Magnetic Resonance Imaging
Multiple Myeloma
/ drug therapy
Tomography, X-Ray Computed
lymphomatoid granulomatosis
methotrexate
multiple myeloma
rheumatoid arthritis
tacrolimus
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
01 Oct 2019
01 Oct 2019
Historique:
pubmed:
28
6
2019
medline:
7
1
2020
entrez:
28
6
2019
Statut:
ppublish
Résumé
A 75-year-old Japanese woman with a 20-year history of rheumatoid arthritis presented with symptomatic bilateral pleural effusion and lung and brain tumors. She had received methotrexate for five years and tacrolimus for one year. A brain biopsy specimen showed the pathological features of lymphoproliferative disease, but a bone marrow biopsy showed proliferation of plasma cells. She was finally diagnosed with coexistent lymphomatoid granulomatosis (LYG) of the brain and lung and multiple myeloma (MM) of the bone marrow and received chemotherapy for both. This report shows that immunodeficient patients are at risk of developing the unusual coexistence of LYG and MM.
Identifiants
pubmed: 31243219
doi: 10.2169/internalmedicine.2811-19
pmc: PMC6815885
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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