Acute Liver Failure Due to Severe Hepatic Metastasis of Small-cell Lung Cancer Producing Adrenocorticotropic Hormone Complicating Ectopic Cushing Syndrome.
ACTH Syndrome, Ectopic
/ complications
Adrenocorticotropic Hormone
/ biosynthesis
Aged
Cushing Syndrome
/ complications
Fatal Outcome
Humans
Hydrocortisone
/ blood
Hyperglycemia
/ etiology
Hypokalemia
/ etiology
Liver Failure, Acute
/ etiology
Liver Neoplasms
/ complications
Lung Neoplasms
/ diagnostic imaging
Male
Small Cell Lung Carcinoma
/ complications
Tomography, X-Ray Computed
Ultrasonography
ACTH-producing tumor
ectopic Cushing syndrome
liver failure
small-cell lung cancer
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Oct 2019
15 Oct 2019
Historique:
pubmed:
28
6
2019
medline:
7
1
2020
entrez:
28
6
2019
Statut:
ppublish
Résumé
A 72-year-old man was admitted to a general hospital with progressive liver dysfunction, hypokalemia, hyperglycemia, and nodules in the lung and liver and then transferred to our institution on the seventh hospital day. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, and neuron-specific enolase concentrations were extremely high. He developed acute liver failure, his consciousness and general condition deteriorated rapidly, and he died on Day 11. At the postmortem examination, he was found to have extensive metastases from small-cell lung cancer, including advanced hepatic metastases. This is the first reported case of acute liver failure caused by metastases derived from an ACTH-producing pulmonary small-cell carcinoma.
Identifiants
pubmed: 31243230
doi: 10.2169/internalmedicine.1976-18
pmc: PMC6859385
doi:
Substances chimiques
Adrenocorticotropic Hormone
9002-60-2
Hydrocortisone
WI4X0X7BPJ
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2977-2982Références
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