Immune evasion before tumour invasion in early lung squamous carcinogenesis.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
07 2019
Historique:
received: 27 11 2018
accepted: 24 05 2019
pubmed: 28 6 2019
medline: 24 3 2020
entrez: 28 6 2019
Statut: ppublish

Résumé

Early detection and treatment are critical for improving the outcome of patients with cancer

Identifiants

pubmed: 31243362
doi: 10.1038/s41586-019-1330-0
pii: 10.1038/s41586-019-1330-0
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

570-575

Références

Goldberg, S. W., Mulshine, J. L., Hagstrom, D. & Pyenson, B. S. An actuarial approach to comparing early stage and late stage lung cancer mortality and survival. Popul. Health Manag. 13, 33–46 (2010).
pubmed: 20158322
Bindea, G. et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39, 782–795 (2013).
pubmed: 24138885
Mlecnik, B. et al. Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J. Clin. Oncol. 29, 610–618 (2011).
pubmed: 21245428
Herbst, R. S., Morgensztern, D. & Boshoff, C. The biology and management of non-small cell lung cancer. Nature 553, 446–454 (2018).
pubmed: 29364287
De Koning, H., Van Der Aalst, C., Ten Haaf, K. & Oudkerk, M. PL02.05 effects of volume CT lung cancer screening: mortality results of the NELSON randomised-controlled population based trial. J. Thorac. Oncol. 13, S185 (2018).
Umar, A., Dunn, B. K. & Greenwald, P. Future directions in cancer prevention. Nat. Rev. Cancer 12, 835–848 (2012).
pubmed: 23151603
Kensler, T. W. et al. Transforming cancer prevention through precision medicine and immune-oncology. Cancer Prev. Res. 9, 2–10 (2016).
Slaughter, D. P., Southwick, H. W. & Smejkal, W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6, 963–968 (1953).
pubmed: 13094644
Kerr, K. M. Pulmonary preinvasive neoplasia. J. Clin. Pathol. 54, 257–271 (2001).
pubmed: 11304841 pmcid: 1731391
Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960–1964 (2006).
pubmed: 17008531
Galon, J., Angell, H. K., Bedognetti, D. & Marincola, F. M. The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures. Immunity 39, 11–26 (2013).
pubmed: 23890060
Pagès, F. et al. International validation of the consensus immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet 391, 2128–2139 (2018).
Pagès, F. et al. In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. J. Clin. Oncol. 27, 5944–5951 (2009).
pubmed: 19858404
Fridman, W. H., Pagès, F., Sautès-Fridman, C. & Galon, J. The immune contexture in human tumours: impact on clinical outcome. Nat. Rev. Cancer 12, 298–306 (2012).
pubmed: 22419253
Gentles, A. J. et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat. Med. 21, 938–945 (2015).
pubmed: 26193342 pmcid: 4852857
Teixeira, V. H. et al. Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions. Nat. Med. 25, 517–525 (2019).
pubmed: 30664780
Wu, S., Powers, S., Zhu, W. & Hannun, Y. A. Substantial contribution of extrinsic risk factors to cancer development. Nature 529, 43–47 (2016).
pubmed: 26675728
Angelova, M. et al. Evolution of metastases in space and time under immune selection. Cell 175, 751–765 (2018).
pubmed: 30318143
Mlecnik, B. et al. The tumor microenvironment and immunoscore are critical determinants of dissemination to distant metastasis. Sci. Transl. Med. 8, 327ra26 (2016).
pubmed: 26912905
Galon, J. & Bruni, D. Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat. Rev. Drug Discov. 18, 197–218 (2019).
pubmed: 30610226
Gandhi, L. et al. Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N. Engl. J. Med. 378, 2078–2092 (2018).
pubmed: 29658856
Reck, M. et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N. Engl. J. Med. 375, 1823–1833 (2016).
Brahmer, J. et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N. Engl. J. Med. 373, 123–135 (2015).
pubmed: 26028407 pmcid: 4681400
Herbst, R. S. et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 387, 1540–1550 (2016).
Antonia, S. J. et al. Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC. N. Engl. J. Med. 379, 2342–2350 (2018).
pubmed: 30280658
Eggermont, A. M. M. et al. Adjuvant pembrolizumab versus placebo in resected stage III melanoma. N. Engl. J. Med. 378, 1789–1801 (2018).
pubmed: 29658430
Forde, P. M. et al. Neoadjuvant PD-1 blockade in resectable lung cancer. N. Engl. J. Med. 378, 1976–1986 (2018).
pubmed: 29658848 pmcid: 6223617
Mascaux, C. et al. Evolution of microRNA expression during human bronchial squamous carcinogenesis. Eur. Respir. J. 33, 352–359 (2009).
pubmed: 19010987
Bota, S. et al. Follow-up of bronchial precancerous lesions and carcinoma in situ using fluorescence endoscopy. Am. J. Respir. Crit. Care Med. 164, 1688–1693 (2001).
pubmed: 11719311
Breuer, R. H. et al. The natural course of preneoplastic lesions in bronchial epithelium. Clin. Cancer Res. 11, 537–543 (2005).
pubmed: 15701838

Auteurs

Céline Mascaux (C)

Department of Intensive Care and Thoracic Oncology, Jules Bordet Institute, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), ULB, Brussels, Belgium. celine.mascaux@chru-strasbourg.fr.
Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. celine.mascaux@chru-strasbourg.fr.
INSERM UMR 1068, CNRS UMR 725, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix-Marseille Université, Marseille, France. celine.mascaux@chru-strasbourg.fr.
Department of Multidisciplinary Oncology and Innovative Therapeutics, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France. celine.mascaux@chru-strasbourg.fr.
Department of Pulmonology, Strasbourg University Hospital, Strasbourg, France. celine.mascaux@chru-strasbourg.fr.
INSERM IRFAC UMR_S1113, Université de Strasbourg, Strasbourg, France. celine.mascaux@chru-strasbourg.fr.

Mihaela Angelova (M)

INSERM, Laboratory of Integrative Cancer Immunology, Centre de Recherche des Cordeliers, Paris, France.
Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Sorbonne Université, Paris, France.
Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Université de Paris, Paris, France.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Angela Vasaturo (A)

INSERM, Laboratory of Integrative Cancer Immunology, Centre de Recherche des Cordeliers, Paris, France.
Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Sorbonne Université, Paris, France.
Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Université de Paris, Paris, France.

Jennifer Beane (J)

Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Kahkeshan Hijazi (K)

Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Geraldine Anthoine (G)

Department of Intensive Care and Thoracic Oncology, Jules Bordet Institute, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), ULB, Brussels, Belgium.

Bénédicte Buttard (B)

INSERM, Laboratory of Integrative Cancer Immunology, Centre de Recherche des Cordeliers, Paris, France.
Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Sorbonne Université, Paris, France.
Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Université de Paris, Paris, France.

Françoise Rothe (F)

Breast Cancer Translational Research Laboratory, Jules Bordet Institute, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), ULB, Brussels, Belgium.

Karen Willard-Gallo (K)

Laboratory of Molecular Immunology, Jules Bordet Institute, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), ULB, Brussels, Belgium.

Annick Haller (A)

Department of Pathology, Jules Bordet Institute, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), ULB, Brussels, Belgium.
Pathology Centre, Strasbourg, France.

Vincent Ninane (V)

Department of Pulmonary Medicine, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), ULB, Brussels, Belgium.

Arsène Burny (A)

Laboratory of Molecular and Cellular Biology, Faculté Universitaire des Sciences Agronomiques de Gembloux (FUSAGx), Gembloux, Belgium.

Jean-Paul Sculier (JP)

Department of Intensive Care and Thoracic Oncology, Jules Bordet Institute, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), ULB, Brussels, Belgium.

Avi Spira (A)

Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Jérôme Galon (J)

INSERM, Laboratory of Integrative Cancer Immunology, Centre de Recherche des Cordeliers, Paris, France. jerome.galon@crc.jussieu.fr.
Equipe Labellisée Ligue Contre le Cancer, Paris, France. jerome.galon@crc.jussieu.fr.
Sorbonne Université, Paris, France. jerome.galon@crc.jussieu.fr.
Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Université de Paris, Paris, France. jerome.galon@crc.jussieu.fr.

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