Identifying Compounds with Genotoxicity Potential Using Tox21 High-Throughput Screening Assays.
Journal
Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448
Informations de publication
Date de publication:
15 07 2019
15 07 2019
Historique:
pubmed:
28
6
2019
medline:
1
7
2020
entrez:
28
6
2019
Statut:
ppublish
Résumé
Genotoxicity is a critical component of a comprehensive toxicological profile. The Tox21 Program used five quantitative high-throughput screening (qHTS) assays measuring some aspect of DNA damage/repair to provide information on the genotoxic potential of over 10 000 compounds. Included were assays detecting activation of p53, increases in the DNA repair protein ATAD5, phosphorylation of H2AX, and enhanced cytotoxicity in DT40 cells deficient in DNA-repair proteins REV3 or KU70/RAD54. Each assay measures a distinct component of the DNA damage response signaling network; >70% of active compounds were detected in only one of the five assays. When qHTS results were compared with results from three standard genotoxicity assays (bacterial mutation,
Identifiants
pubmed: 31243984
doi: 10.1021/acs.chemrestox.9b00053
pmc: PMC6740247
mid: NIHMS1534536
doi:
Substances chimiques
Mutagens
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1384-1401Subventions
Organisme : Intramural NIH HHS
ID : Z99 ES999999
Pays : United States
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