Biological Significance of microRNA Biomarkers in ALS-Innocent Bystanders or Disease Culprits?
ALS
ALS genes
MND
amyotrophic lateral sclerosis
bioinformatics
biomarker
microRNA
neurodegeneration
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2019
2019
Historique:
received:
04
03
2019
accepted:
15
05
2019
entrez:
28
6
2019
pubmed:
28
6
2019
medline:
28
6
2019
Statut:
epublish
Résumé
MicroRNAs (miRNAs) represent potential biomarkers for neurodegenerative disorders including amyotrophic lateral sclerosis (ALS). However, whether expression changes of individual miRNAs are simply an indication of cellular dysfunction and degeneration, or actually promote functional changes in target gene expression relevant to disease pathogenesis, is unclear. Here we used bioinformatics to test the hypothesis that ALS-associated miRNAs exert their effects through targeting genes implicated in disease etiology. We documented deregulated miRNAs identified in studies of ALS patients, noting variations in participants, tissue samples, miRNA detection or quantification methods used, and functional or bioinformatic assessments (if performed). Despite lack of experimental standardization, overlap of many deregulated miRNAs between studies was noted; however, direction of reported expression changes did not always concur. The use of
Identifiants
pubmed: 31244752
doi: 10.3389/fneur.2019.00578
pmc: PMC6579821
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
578Subventions
Organisme : Motor Neurone Disease Association
ID : LAYFIELD/OCT16/887-792
Pays : United Kingdom
Références
Nat Rev Genet. 2004 Jul;5(7):522-31
pubmed: 15211354
Nat Cell Biol. 2007 Jun;9(6):654-9
pubmed: 17486113
Cell Res. 2008 Oct;18(10):997-1006
pubmed: 18766170
Nat Neurosci. 2009 Apr;12(4):399-408
pubmed: 19287386
Nat Rev Genet. 2010 Sep;11(9):597-610
pubmed: 20661255
Clin Chem. 2010 Nov;56(11):1733-41
pubmed: 20847327
Bioinformatics. 2012 Mar 15;28(6):771-6
pubmed: 22285563
Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3347-52
pubmed: 22323604
Nat Neurosci. 2012 Apr 08;15(5):697-699
pubmed: 22484572
Gene. 2012 Oct 15;508(1):35-40
pubmed: 22903028
Neurobiol Dis. 2013 Jan;49:107-17
pubmed: 22975021
J Clin Endocrinol Metab. 2013 Jul;98(7):3068-79
pubmed: 23666971
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W169-73
pubmed: 23680784
Mol Brain. 2013 May 24;6:26
pubmed: 23705811
Front Genet. 2013 Jun 28;4:119
pubmed: 23825476
Int J Clin Exp Pathol. 2013 Aug 15;6(9):1826-38
pubmed: 24040447
PLoS One. 2013 Oct 15;8(10):e76055
pubmed: 24143176
Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73
pubmed: 24275495
Front Mol Neurosci. 2013 Nov 26;6:39
pubmed: 24324397
Exp Neurol. 2014 Dec;262 Pt B:127-37
pubmed: 24613827
Neuropathol Appl Neurobiol. 2015 Feb;41(2):201-26
pubmed: 24750211
JMIR Mhealth Uhealth. 2013 Sep 04;1(2):e18
pubmed: 25098641
Adv Drug Deliv Rev. 2015 Jun 29;87:3-14
pubmed: 25979468
EMBO J. 2015 Nov 3;34(21):2633-51
pubmed: 26330466
Clin Neuropathol. 2016 Jan-Feb;35(1):22-30
pubmed: 26588026
Mol Cell Neurosci. 2016 Mar;71:34-45
pubmed: 26704906
Nucleic Acids Res. 2016 May 5;44(8):3865-77
pubmed: 26921406
Biomed Res Int. 2016;2016:5930621
pubmed: 27195289
Br Med Bull. 2016 Sep;119(1):87-98
pubmed: 27450455
Front Mol Neurosci. 2016 Aug 17;9:69
pubmed: 27582688
Int J Mol Sci. 2016 Dec 09;17(12):
pubmed: 27941681
J Neurosci. 2017 May 31;37(22):5574-5586
pubmed: 28416596
Hum Mol Genet. 2017 Sep 1;26(17):3409-3420
pubmed: 28637335
Sci Rep. 2017 Aug 25;7(1):9538
pubmed: 28842714
Sci Rep. 2017 Aug 30;7(1):10046
pubmed: 28855684
J Neurol Sci. 2017 Sep 15;380:58-63
pubmed: 28870590
J Neurochem. 2018 Apr;145(1):51-67
pubmed: 28960306
Front Pharmacol. 2017 Oct 25;8:770
pubmed: 29118714
Nucleic Acids Res. 2018 Jan 4;46(D1):D296-D302
pubmed: 29126174
J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):20-27
pubmed: 29193905
Front Neurosci. 2018 Jan 09;11:731
pubmed: 29375285
Trends Genet. 2018 Jun;34(6):404-423
pubmed: 29605155
Brain Behav. 2018 Feb 19;8(4):e00941
pubmed: 29670823
Life Sci. 2018 Jun 15;203:242-245
pubmed: 29709651
Mol Neurobiol. 2019 Mar;56(3):2137-2158
pubmed: 29995256
Degener Neurol Neuromuscul Dis. 2016 May 13;6:49-64
pubmed: 30050368
J Alzheimers Dis. 2018;65(2):455-464
pubmed: 30056425
Front Genet. 2018 Aug 14;9:310
pubmed: 30154826
J Mol Neurosci. 2018 Dec;66(4):617-628
pubmed: 30415446
Cells. 2018 Nov 20;7(11):null
pubmed: 30463376
Brain Res. 2019 Apr 1;1708:100-108
pubmed: 30552897
BMC Med Genomics. 2019 Jan 10;12(1):7
pubmed: 30630471
Front Neurol. 2019 Mar 07;10:186
pubmed: 30899244
FASEB J. 2019 Jul;33(7):8648-8665
pubmed: 30995872