Metabolic reprogramming: an innate cellular defence mechanism against intracellular bacteria?
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
30
01
2019
revised:
24
05
2019
accepted:
24
05
2019
pubmed:
28
6
2019
medline:
25
7
2020
entrez:
28
6
2019
Statut:
ppublish
Résumé
The limited metabolic resources of a cell represent an intriguing 'conflict of interest' during host-pathogen interactions, as the battle for nutrients might determine the outcome of an infection. To adapt their metabolic needs, innate immune cells such as monocytes, macrophages or dendritic cells reprogram their metabolism upon activation by microbial compounds. In turn, infection by intracellular bacteria provokes metabolic alterations of the host cell that benefit the pathogen. Here, we discuss the state-of-the-art knowledge on metabolic reprogramming of host cells upon activation or infection with intracellular bacteria. The study of the host-driven and pathogen-driven metabolic alterations that seem to co-exist during infection is an emerging field that will define the metabolic pathways that might be targeted to combat infection.
Identifiants
pubmed: 31247377
pii: S0952-7915(18)30128-6
doi: 10.1016/j.coi.2019.05.009
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-123Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.