Comparison of the Effectiveness of Lifestyle Modification with Other Treatments on the Incidence of Type 2 Diabetes in People at High Risk: A Network Meta-Analysis.
Diabetes Mellitus, Type 2
/ diagnosis
Diet, Healthy
Exercise
Healthy Lifestyle
Humans
Hypoglycemic Agents
/ therapeutic use
Hypolipidemic Agents
/ therapeutic use
Incidence
Network Meta-Analysis
Protective Factors
Randomized Controlled Trials as Topic
Risk Assessment
Risk Factors
Risk Reduction Behavior
Treatment Outcome
diet
high risk of type 2 diabetes
lifestyle modification
medication
network meta-analysis
randomized controlled trial
systematic review
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
19 Jun 2019
19 Jun 2019
Historique:
received:
01
05
2019
revised:
11
06
2019
accepted:
16
06
2019
entrez:
29
6
2019
pubmed:
30
6
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Many clinical trials have been conducted to verify the effects of interventions for prevention of type 2 diabetes (T2D) using different treatments and outcomes. The aim of this study was to compare the effectiveness of lifestyle modifications (LM) with other treatments in persons at high risk of T2D by a network meta-analysis (NMA). Searches were performed of PUBMED up to January 2018 to identify randomized controlled trials. The odds ratio (OR) with onset of T2D at 1 year in the intervention group (LM, dietary, exercise, or medication) versus a control group (standard treatments or placebo) were the effect sizes. Frequentist and Bayesian NMAs were conducted. Forty-seven interventions and 12 treatments (20,113 participants) were used for the analyses. The OR in the LM was approximately 0.46 (95% CI: 0.33 to 0.61) times lower compared to the standard intervention by the Bayesian approach. The effects of LM compared to other treatments by indirect comparisons were not significant. This meta-analysis further strengthened the evidence that LM reduces the onset of T2D compared to standard and placebo interventions and appears to be at least as effective as nine other treatments in preventing T2D.
Sections du résumé
BACKGROUND
BACKGROUND
Many clinical trials have been conducted to verify the effects of interventions for prevention of type 2 diabetes (T2D) using different treatments and outcomes. The aim of this study was to compare the effectiveness of lifestyle modifications (LM) with other treatments in persons at high risk of T2D by a network meta-analysis (NMA).
METHODS
METHODS
Searches were performed of PUBMED up to January 2018 to identify randomized controlled trials. The odds ratio (OR) with onset of T2D at 1 year in the intervention group (LM, dietary, exercise, or medication) versus a control group (standard treatments or placebo) were the effect sizes. Frequentist and Bayesian NMAs were conducted.
RESULTS
RESULTS
Forty-seven interventions and 12 treatments (20,113 participants) were used for the analyses. The OR in the LM was approximately 0.46 (95% CI: 0.33 to 0.61) times lower compared to the standard intervention by the Bayesian approach. The effects of LM compared to other treatments by indirect comparisons were not significant.
CONCLUSIONS
CONCLUSIONS
This meta-analysis further strengthened the evidence that LM reduces the onset of T2D compared to standard and placebo interventions and appears to be at least as effective as nine other treatments in preventing T2D.
Identifiants
pubmed: 31248094
pii: nu11061373
doi: 10.3390/nu11061373
pmc: PMC6627198
pii:
doi:
Substances chimiques
Hypoglycemic Agents
0
Hypolipidemic Agents
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Références
Diabet Med. 1999 Jun;16(6):477-81
pubmed: 10391395
Aust N Z J Obstet Gynaecol. 1999 May;39(2):162-6
pubmed: 10755770
Arch Intern Med. 2000 May 8;160(9):1321-6
pubmed: 10809036
Biometrics. 2000 Jun;56(2):455-63
pubmed: 10877304
Diabetes Res Clin Pract. 2001 Apr;52(1):29-43
pubmed: 11182214
N Engl J Med. 2002 Feb 7;346(6):393-403
pubmed: 11832527
Lancet. 2002 Jun 15;359(9323):2072-7
pubmed: 12086760
Diabetes Care. 2002 Sep;25(9):1504-10
pubmed: 12196418
Diabetes Care. 2003 Dec;26(12):3209-14
pubmed: 14633803
Diabetes Care. 2003 Dec;26(12):3230-6
pubmed: 14633807
Diabetes Care. 2004 Jan;27(1):155-61
pubmed: 14693982
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Apr;24(4):317-20
pubmed: 15143717
Diabetes Res Clin Pract. 2005 Feb;67(2):152-62
pubmed: 15649575
Diabetes Care. 2005 Nov;28(11):2780-6
pubmed: 16249558
Diabetologia. 2006 Feb;49(2):289-97
pubmed: 16391903
J Intern Med. 2006 Jun;259(6):553-60
pubmed: 16704555
N Engl J Med. 2006 Oct 12;355(15):1551-62
pubmed: 16980380
BMJ. 2007 Feb 10;334(7588):299
pubmed: 17237299
Diabet Med. 2008 May;25(5):597-605
pubmed: 18445174
Diabetes Care. 2008 Oct;31(10):1949-54
pubmed: 18591401
Diabetologia. 2009 Jun;52(6):1019-26
pubmed: 19277602
Lancet. 2009 May 9;373(9675):1607-14
pubmed: 19395079
Diabetes Care. 2009 Aug;32(8):1404-10
pubmed: 19602539
BMC Public Health. 2009 Sep 16;9:342
pubmed: 19758428
Lancet. 2010 Jul 10;376(9735):103-11
pubmed: 20605202
J Clin Epidemiol. 2011 Feb;64(2):163-71
pubmed: 20688472
Diabetes Care. 2011 Jan;34(1):14-9
pubmed: 20929998
BMC Public Health. 2011 Jan 17;11(1):40
pubmed: 21235825
N Engl J Med. 2011 Mar 24;364(12):1104-15
pubmed: 21428766
Diabetes Metab. 2011 Nov;37(5):410-8
pubmed: 21489843
Adv Ther. 2011 Jun;28(6):511-9
pubmed: 21533568
Wei Sheng Yan Jiu. 2011 May;40(3):331-3
pubmed: 21695906
BMC Med. 2011 Jun 27;9:79
pubmed: 21707969
Arch Intern Med. 2011 Aug 8;171(15):1352-60
pubmed: 21824948
Am J Public Health. 2012 Feb;102(2):336-42
pubmed: 22390448
Diabet Med. 2012 Aug;29(8):e223-31
pubmed: 22416789
Br J Nutr. 2013 Feb 14;109(3):487-92
pubmed: 23021205
BMC Med. 2012 Nov 14;10:138
pubmed: 23151238
J Clin Endocrinol Metab. 2014 Feb;99(2):648-55
pubmed: 24432995
Diabetes Res Clin Pract. 2013 Dec;102(3):158-66
pubmed: 24466598
Complement Ther Med. 2014 Oct;22(5):842-50
pubmed: 25440374
Ann Intern Med. 2015 Jun 2;162(11):777-84
pubmed: 26030634
Res Synth Methods. 2012 Jun;3(2):98-110
pubmed: 26062084
Res Synth Methods. 2012 Jun;3(2):111-25
pubmed: 26062085
Eur J Epidemiol. 2015 Jul;30(7):529-42
pubmed: 26092138
Diabetes Care. 2016 Oct;39(10):1760-7
pubmed: 27504014
Front Endocrinol (Lausanne). 2017 Jan 24;8:6
pubmed: 28167928
BMC Med. 2017 Jul 19;15(1):131
pubmed: 28720102
BMJ. 2017 Sep 13;358:j3932
pubmed: 28903924
Diabetes Ther. 2017 Dec;8(6):1227-1242
pubmed: 29027648
JAMA Intern Med. 2017 Dec 1;177(12):1808-1817
pubmed: 29114778
Cochrane Database Syst Rev. 2017 Dec 04;12:CD003054
pubmed: 29205264
Diabetes Care. 2018 May;41(5):917-928
pubmed: 29567642
Diabetes Care. 2018 Jul;41(7):1526-1534
pubmed: 29934481
Nutrients. 2019 Feb 05;11(2):null
pubmed: 30764511
Diabetes Care. 1997 Apr;20(4):537-44
pubmed: 9096977