Heart rate reserve is a long-term risk predictor in women undergoing myocardial perfusion imaging.
Adenosine
/ administration & dosage
Aged
Female
Heart
/ drug effects
Heart Diseases
/ diagnosis
Heart Rate
Humans
Middle Aged
Myocardial Perfusion Imaging
/ methods
Nitrogen Radioisotopes
Positron-Emission Tomography
/ methods
Radiopharmaceuticals
Sensitivity and Specificity
Vasodilator Agents
/ administration & dosage
13N-ammonia PET
Adenosine
Coronary artery disease
Heart rate response
Women
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
09
02
2019
accepted:
29
04
2019
pubmed:
30
6
2019
medline:
15
9
2020
entrez:
30
6
2019
Statut:
ppublish
Résumé
Although women with cardiovascular disease experience relatively worse outcomes as compared to men, substantial knowledge gaps remain regarding the unique female determinants of cardiovascular risk. Heart rate (HR) responses to vasodilator stress mirror autonomic activity and may carry important long-term prognostic information in women. Hemodynamic changes during adenosine stress were recorded in a total of 508 consecutive patients (104 women) undergoing clinically indicated Blunted HRR to adenosine stress adds incremental prognostic value for long-term cardiovascular outcomes in women beyond that provided by traditional risk factors and imaging findings.
Sections du résumé
BACKGROUND
BACKGROUND
Although women with cardiovascular disease experience relatively worse outcomes as compared to men, substantial knowledge gaps remain regarding the unique female determinants of cardiovascular risk. Heart rate (HR) responses to vasodilator stress mirror autonomic activity and may carry important long-term prognostic information in women.
METHODS AND RESULTS
RESULTS
Hemodynamic changes during adenosine stress were recorded in a total of 508 consecutive patients (104 women) undergoing clinically indicated
CONCLUSION
CONCLUSIONS
Blunted HRR to adenosine stress adds incremental prognostic value for long-term cardiovascular outcomes in women beyond that provided by traditional risk factors and imaging findings.
Identifiants
pubmed: 31254034
doi: 10.1007/s00259-019-04344-1
pii: 10.1007/s00259-019-04344-1
doi:
Substances chimiques
Nitrogen Radioisotopes
0
Radiopharmaceuticals
0
Vasodilator Agents
0
Adenosine
K72T3FS567
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2032-2041Subventions
Organisme : Helmut Horten Foundation
ID : research grant
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : research grant
Organisme : Novartis Stiftung für Medizinisch-Biologische Forschung
ID : research grant
Organisme : Olga Mayenfisch Foundation
ID : research grant
Organisme : OPO Foundation
ID : research grant
Organisme : Schweizerische Herzstiftung
ID : research grant
Organisme : Iten-Kohaut Foundation
ID : research grant
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