CREB deletion increases resilience to stress and downregulates inflammatory gene expression in the hippocampus.
Animals
Antidepressive Agents
/ pharmacology
Brain
/ metabolism
Cyclic AMP Response Element-Binding Protein
/ genetics
Depression
Gene Expression
/ drug effects
Gene Expression Regulation
/ genetics
Hippocampus
/ metabolism
Inflammation
/ genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Phosphorylation
/ drug effects
Stress, Psychological
/ genetics
Temporal Lobe
/ metabolism
Toll-Like Receptor 1
/ drug effects
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
24
04
2019
revised:
05
06
2019
accepted:
22
06
2019
pubmed:
1
7
2019
medline:
15
8
2020
entrez:
1
7
2019
Statut:
ppublish
Résumé
The transcription factor CREB (cyclic AMP response element (CRE)-binding protein) is implicated in the pathophysiology and treatment of depression. Structural and functional studies in both animals and humans suggest that abnormalities of the hippocampus may play a role in depression. CREB regulates thousands of genes, yet to date, only a handful that mediate depression or antidepressant response have been identified as relevant CREB targets. In order to comprehensively identify genes regulated by CREB in the hippocampus, we employed translating ribosome affinity purification (TRAP) to detect actively translating mRNAs in wild type and CREB-deficient mice. Using Creb
Identifiants
pubmed: 31255680
pii: S0889-1591(19)30433-7
doi: 10.1016/j.bbi.2019.06.035
pmc: PMC6754757
mid: NIHMS1533936
pii:
doi:
Substances chimiques
Antidepressive Agents
0
Creb1 protein, mouse
0
Cyclic AMP Response Element-Binding Protein
0
Toll-Like Receptor 1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
388-398Subventions
Organisme : NIDA NIH HHS
ID : R01 DA041180
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA044017
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA028874
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH106442
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Références
J Neurosci. 2000 Jun 1;20(11):4030-6
pubmed: 10818138
Psychoneuroendocrinology. 2007 Jun;32(5):516-31
pubmed: 17482371
Bioessays. 2007 Oct;29(10):957-61
pubmed: 17876779
Biol Psychiatry. 2001 May 1;49(9):753-62
pubmed: 11331083
Psychopharmacology (Berl). 2008 Nov;201(1):15-28
pubmed: 18677617
J Vis Exp. 2013 Dec 24;(82):50978
pubmed: 24429507
PLoS One. 2007 May 09;2(5):e431
pubmed: 17487276
Int J Neuropsychopharmacol. 2010 Apr;13(3):321-34
pubmed: 20003619
Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4282-4287
pubmed: 29610348
Neuropsychopharmacology. 2010 Nov;35(12):2378-91
pubmed: 20686454
Nat Protoc. 2014;9(6):1282-91
pubmed: 24810037
Physiol Behav. 1995 Feb;57(2):241-8
pubmed: 7716198
Bioinformatics. 2011 Sep 15;27(18):2518-28
pubmed: 21775302
J Am Assoc Lab Anim Sci. 2011 Sep;50(5):686-94
pubmed: 22330716
Biol Psychiatry. 2004 Aug 1;56(3):151-60
pubmed: 15271583
J Neurosci. 2007 Jul 18;27(29):7860-8
pubmed: 17634380
Psychopharmacology (Berl). 1981;73(2):157-60
pubmed: 6453354
J Neurosci. 2013 Aug 21;33(34):13673-85
pubmed: 23966689
J Psychiatr Res. 2014 Jun;53:62-8
pubmed: 24565447
Neuropsychopharmacology. 2017 Jul;42(8):1670-1678
pubmed: 28094283
Neuropharmacology. 2003 Sep;45(4):553-63
pubmed: 12907316
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4459-64
pubmed: 15753290
Lancet. 1998 Nov 28;352(9142):1754-5
pubmed: 9848357
J Clin Invest. 2014 Mar;124(3):1242-54
pubmed: 24569379
Mol Psychiatry. 2019 Jul;24(7):987-994
pubmed: 30214045
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1920-5
pubmed: 12578963
Behav Brain Res. 2002 May 14;132(2):203-13
pubmed: 11997150
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12317-22
pubmed: 20566846
J Vis Exp. 2011 May 17;(51):
pubmed: 21633328
J Neurosci. 1996 Apr 1;16(7):2365-72
pubmed: 8601816
Pharmacol Rev. 2006 Mar;58(1):115-34
pubmed: 16507885
Trends Immunol. 2006 Jan;27(1):24-31
pubmed: 16316783
J Biosci. 2006 Sep;31(3):423-34
pubmed: 17006024
Neurosci Biobehav Rev. 1992 Winter;16(4):507-17
pubmed: 1480347
J Cell Mol Med. 2010 Nov;14(11):2592-603
pubmed: 20629986
Inhal Toxicol. 2006 Oct;18(11):911-8
pubmed: 16864409
J Neurochem. 2019 Apr;149(1):111-125
pubmed: 30697736
Mol Metab. 2014 Aug 23;3(8):803-12
pubmed: 25379405
Nucleic Acids Res. 2009 Jan;37(1):1-13
pubmed: 19033363
J Neurosci. 2002 Apr 15;22(8):3262-8
pubmed: 11943827
Nat Rev Neurosci. 2008 Jan;9(1):46-56
pubmed: 18073775
J Immunol. 2002 Jul 1;169(1):10-4
pubmed: 12077222
Behav Brain Res. 2004 Nov 5;155(1):135-46
pubmed: 15325787
Psychopharmacology (Berl). 2016 May;233(9):1707-14
pubmed: 26415953
Handb Clin Neurol. 2018;157:599-621
pubmed: 30459027
Nucleic Acids Res. 2017 Jan 4;45(D1):D362-D368
pubmed: 27924014
Brain Res. 2003 Nov 21;991(1-2):123-32
pubmed: 14575884
Cell. 2004 Dec 29;119(7):1041-54
pubmed: 15620361
Annu Rev Psychol. 1997;48:191-214
pubmed: 9046559