Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR.
Journal
Progress in biophysics and molecular biology
ISSN: 1873-1732
Titre abrégé: Prog Biophys Mol Biol
Pays: England
ID NLM: 0401233
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
22
05
2019
accepted:
24
06
2019
pubmed:
1
7
2019
medline:
19
5
2020
entrez:
1
7
2019
Statut:
ppublish
Résumé
ATM, ATR and DNA-PKCs are key effectors of DNA Damage response and have been extensively linked to tumourigenesis and survival of cancer cells after radio/chemotherapy. Despite numerous efforts, the structures of these proteins remained elusive until very recently. The resolution revolution in Cryo-EM allowed for molecular details of these proteins to be seen for the first time. Here we provide a comprehensive review of the structures of ATM, ATR and DNA-PKcs and their complexes and expand with observations springing from our own cryo-EM studies. These observations include a novel conformation of ATR and novel dimeric arrangements of DNA-PKcs.
Identifiants
pubmed: 31255703
pii: S0079-6107(19)30119-1
doi: 10.1016/j.pbiomolbio.2019.06.003
pii:
doi:
Substances chimiques
Site-Specific DNA-Methyltransferase (Adenine-Specific)
EC 2.1.1.72
ATR protein, human
EC 2.7.11.1
Ataxia Telangiectasia Mutated Proteins
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4-16Subventions
Organisme : Medical Research Council
ID : MC_U105184308
Pays : United Kingdom
Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.