Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner.
Adipose Tissue, White
/ metabolism
Animals
Diet, High-Fat
Glucose Intolerance
Humans
Intra-Abdominal Fat
/ metabolism
Lipid Metabolism
/ genetics
Lipids
/ analysis
Macrophages
/ cytology
Membrane Glycoproteins
/ deficiency
Mice
Mice, Inbred C57BL
Mice, Knockout
Monocytes
/ cytology
Obesity
/ metabolism
Receptors, Immunologic
/ deficiency
Signal Transduction
Single-Cell Analysis
Alzheimer disease
Trem2 pathway
fatty liver diseases
immunology
macrophages
metabolic diseases
metabolism
obesity
single-cell genomics
systems biology
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
25 07 2019
25 07 2019
Historique:
received:
25
02
2019
revised:
18
04
2019
accepted:
28
05
2019
pubmed:
2
7
2019
medline:
28
4
2020
entrez:
2
7
2019
Statut:
ppublish
Résumé
Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the molecular regulators that drive adipose tissue immune cell remodeling during obesity remain largely unknown. Using index and transcriptional single-cell sorting, we comprehensively map all adipose tissue immune populations in both mice and humans during obesity. We describe a novel and conserved Trem2
Identifiants
pubmed: 31257031
pii: S0092-8674(19)30625-7
doi: 10.1016/j.cell.2019.05.054
pmc: PMC7068689
mid: NIHMS1561325
pii:
doi:
Substances chimiques
Lipids
0
Membrane Glycoproteins
0
Receptors, Immunologic
0
Trem2 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
686-698.e14Subventions
Organisme : NICHD NIH HHS
ID : R25 HD082842
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK116668
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR069589
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK050306
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056341
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK049780
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK019525
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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