Intramuscular inflammatory and resolving lipid profile responses to an acute bout of resistance exercise in men.
Exercise recovery
inflammation
inflammatory resolution
lipids
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
11
04
2019
accepted:
26
04
2019
entrez:
2
7
2019
pubmed:
2
7
2019
medline:
3
6
2020
Statut:
ppublish
Résumé
Lipid mediators including classical arachidonic acid-derived eicosanoids (e.g. prostaglandins and leukotrienes) and more recently identified specialized pro-resolving-mediator metabolites of the omega-3 fatty acids play essential roles in initiation, self-limitation, and active resolution of acute inflammatory responses. In this study, we examined the bioactive lipid mediator profile of human skeletal muscle at rest and following acute resistance exercise. Twelve male subjects completed a single bout of maximal isokinetic unilateral knee extension exercise and muscle biopsies were taken from the m.vastus lateralis before and at 2, 4, and 24 h of recovery. Muscle tissue lipid mediator profile was analyzed via liquid chromatography-mass spectrometry (LC-MS)-based targeted lipidomics. At 2 h postexercise, there was an increased intramuscular abundance of cyclooxygenase (COX)-derived thromboxanes (TXB
Identifiants
pubmed: 31257737
doi: 10.14814/phy2.14108
pmc: PMC6599756
doi:
Substances chimiques
Arachidonic Acids
0
Prostaglandins
0
Thromboxanes
0
Eicosapentaenoic Acid
AAN7QOV9EA
Lipoxygenase
EC 1.13.11.12
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14108Subventions
Organisme : NCRR NIH HHS
ID : S10 RR027926
Pays : United States
Informations de copyright
© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.
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