Cerebral Gray and White Matter Involvement in Anorexia Nervosa Evaluated by T1, T2, and T2* Mapping.
anorexia nervosa
brain
dehydration
magnetic resonance imaging
myelin sheath
Journal
Journal of neuroimaging : official journal of the American Society of Neuroimaging
ISSN: 1552-6569
Titre abrégé: J Neuroimaging
Pays: United States
ID NLM: 9102705
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
25
04
2019
revised:
29
05
2019
accepted:
14
06
2019
pubmed:
2
7
2019
medline:
20
6
2020
entrez:
2
7
2019
Statut:
ppublish
Résumé
Changes in the brain composition of anorexics could potentially be expected, opening the door to new imaging approaches where quantitative and qualitative MRI have a role. Our purpose was to investigate anorexia-related brain dehydration and myelin depletion by analyzing T1, T2, and T2* relaxation times of different brain structures in anorexics and controls. Thirty-eight anorexic female patients (mean age, 26.2 years; age range, 16.2-48.7 years; mean BMI, 14.5 kg/m The T1 relaxation times of gray and white matter were significantly lower in anorexics (P = .009), whereas the T2 relaxation times of gray matter were higher (P < .001). There were no statistically significant differences in gray matter T2* relaxation times or in white matter T2 and T2* relaxation times between anorexics and controls. Occipital lobe gray matter showed the shortest T1, T2, and T2* relaxation times of all brain regions (P < .05). T1 shortening in anorexics suggests both dehydration and myelin loss, whereas T2 prolongation points toward myelin loss (myelin water has lower T2), which seems to be less discernible in white matter. Shorter overall relaxation times in the most posterior regions of the brain suggest higher iron content.
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
Changes in the brain composition of anorexics could potentially be expected, opening the door to new imaging approaches where quantitative and qualitative MRI have a role. Our purpose was to investigate anorexia-related brain dehydration and myelin depletion by analyzing T1, T2, and T2* relaxation times of different brain structures in anorexics and controls.
METHODS
METHODS
Thirty-eight anorexic female patients (mean age, 26.2 years; age range, 16.2-48.7 years; mean BMI, 14.5 kg/m
RESULTS
RESULTS
The T1 relaxation times of gray and white matter were significantly lower in anorexics (P = .009), whereas the T2 relaxation times of gray matter were higher (P < .001). There were no statistically significant differences in gray matter T2* relaxation times or in white matter T2 and T2* relaxation times between anorexics and controls. Occipital lobe gray matter showed the shortest T1, T2, and T2* relaxation times of all brain regions (P < .05).
CONCLUSIONS
CONCLUSIONS
T1 shortening in anorexics suggests both dehydration and myelin loss, whereas T2 prolongation points toward myelin loss (myelin water has lower T2), which seems to be less discernible in white matter. Shorter overall relaxation times in the most posterior regions of the brain suggest higher iron content.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
598-604Informations de copyright
© 2019 by the American Society of Neuroimaging.
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