A Potential Role For Apparent Diffusion Coefficient in the Diagnosis of Trilateral Retinoblastoma.


Journal

Journal of pediatric hematology/oncology
ISSN: 1536-3678
Titre abrégé: J Pediatr Hematol Oncol
Pays: United States
ID NLM: 9505928

Informations de publication

Date de publication:
04 2020
Historique:
pubmed: 2 7 2019
medline: 18 8 2020
entrez: 2 7 2019
Statut: ppublish

Résumé

We attempted to investigate the potential role for apparent diffusion coefficient (ADC) to diagnose trilateral retinoblastoma (TRb) by retrospectively reviewing brain magnetic resonance images of retinoblastoma patients. Observations: The median ADC measured 620.95 for TRb (n=6) and 1238.5 for normal pineal gland in bilateral retinoblastoma (n=8). Monitoring ADC trends aided in establishing the appropriate diagnoses in 3 patients (2 TRb, 1 benign pineal cyst). Conclusions: Our results provide baseline reference data and describe the importance of downward trending ADC which should prompt consideration of TRb. Unchanged high/nonrestricted values (>1000) may distinguish those with benign pineal tissue and obviate invasive neurosurgical procedures.

Identifiants

pubmed: 31259824
doi: 10.1097/MPH.0000000000001523
pii: 00043426-202004000-00016
pmc: PMC8082522
mid: NIHMS1688483
doi:

Types de publication

Case Reports Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

238-243

Subventions

Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States

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Auteurs

Sameer Farouk Sait (S)

Departments of Pediatrics.
Pediatrics.

Sofia Haque (S)

Radiology.
Departments of Radiology.

Sasan Karimi (S)

Radiology.
Departments of Radiology.

David H Abramson (DH)

Surgery.
Ophthalmology.

Mark M Souweidane (MM)

Neurosurgery, Memorial Sloan Kettering Cancer Center.
Neurosurgery, Weill Cornell Medical College, New York, NY.

Ira J Dunkel (IJ)

Departments of Pediatrics.
Pediatrics.

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Classifications MeSH