Association between posttraumatic stress disorder severity and amygdala habituation to fearful stimuli.
amygdala
fMRI
fear
habituation
trauma
Journal
Depression and anxiety
ISSN: 1520-6394
Titre abrégé: Depress Anxiety
Pays: United States
ID NLM: 9708816
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
24
09
2018
revised:
01
05
2019
accepted:
11
05
2019
entrez:
2
7
2019
pubmed:
2
7
2019
medline:
5
11
2019
Statut:
ppublish
Résumé
Amygdala hyperreactivity to threat has been proposed to be a causal contributor to posttraumatic stress disorder (PTSD). However, emerging literature in healthy samples shows higher test-retest reliability for amygdala habituation (the change over time in response to repeated stimuli) than for its reactivity to threat. Amygdala habituation has received relatively little attention in relationship to PTSD, despite the key role of this region in the etiology of the disorder. Thus, we investigated habituation to repeated fearful face stimuli and PTSD, in a large sample of trauma exposed African American women. African American women (N = 100) were recruited from a nonprofit hospital serving a largely low-income population with a high risk of trauma exposure. Participants underwent functional magnetic resonance imaging, passively viewing fearful and neutral face stimuli, and reported their history of trauma exposure and current PTSD symptoms. We examined associations between PTSD symptom severity and amygdala reactivity (fearful > neutral) and habituation (early > late) to fearful faces. Secondary analyses tested whether amygdala habituation to fearful faces mediated the association between childhood trauma and PTSD. PTSD symptom severity and PTSD status (based on self-report measure) were both positively associated with amygdala habituation to repeated fearful face stimuli. Whole-brain analysis showed that this association extended to the bilateral hippocampus and left fusiform gyrus. The association held when controlling for trauma history and depressive symptoms. Amygdala habituation to fearful faces partially mediated the association between childhood trauma severity and PTSD symptom severity. Individuals with greater PTSD symptom severity showed greater amygdala habituation to social threat cues (fearful faces), and greater habituation may partly explain the association between childhood trauma exposure and current PTSD symptoms. Further examination of the dynamics of the amygdala response to threat cues may lead to new insights in the understanding and treatment of stress-related disorders.
Sections du résumé
BACKGROUND
Amygdala hyperreactivity to threat has been proposed to be a causal contributor to posttraumatic stress disorder (PTSD). However, emerging literature in healthy samples shows higher test-retest reliability for amygdala habituation (the change over time in response to repeated stimuli) than for its reactivity to threat. Amygdala habituation has received relatively little attention in relationship to PTSD, despite the key role of this region in the etiology of the disorder. Thus, we investigated habituation to repeated fearful face stimuli and PTSD, in a large sample of trauma exposed African American women.
METHODS
African American women (N = 100) were recruited from a nonprofit hospital serving a largely low-income population with a high risk of trauma exposure. Participants underwent functional magnetic resonance imaging, passively viewing fearful and neutral face stimuli, and reported their history of trauma exposure and current PTSD symptoms. We examined associations between PTSD symptom severity and amygdala reactivity (fearful > neutral) and habituation (early > late) to fearful faces. Secondary analyses tested whether amygdala habituation to fearful faces mediated the association between childhood trauma and PTSD.
RESULTS
PTSD symptom severity and PTSD status (based on self-report measure) were both positively associated with amygdala habituation to repeated fearful face stimuli. Whole-brain analysis showed that this association extended to the bilateral hippocampus and left fusiform gyrus. The association held when controlling for trauma history and depressive symptoms. Amygdala habituation to fearful faces partially mediated the association between childhood trauma severity and PTSD symptom severity.
CONCLUSION
Individuals with greater PTSD symptom severity showed greater amygdala habituation to social threat cues (fearful faces), and greater habituation may partly explain the association between childhood trauma exposure and current PTSD symptoms. Further examination of the dynamics of the amygdala response to threat cues may lead to new insights in the understanding and treatment of stress-related disorders.
Identifiants
pubmed: 31260599
doi: 10.1002/da.22928
pmc: PMC6943827
mid: NIHMS1065547
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
647-658Subventions
Organisme : NIMH NIH HHS
ID : R56 MH071537
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH098212
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH118771
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117009
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL130025
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000454
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH101380
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD085850
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH071537
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000039
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH096764
Pays : United States
Organisme : NIMH NIH HHS
ID : F32 MH101976
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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