E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis.
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
27
02
2019
revised:
28
05
2019
accepted:
17
06
2019
pubmed:
2
7
2019
medline:
16
7
2020
entrez:
2
7
2019
Statut:
ppublish
Résumé
The cell adhesion molecule E-cadherin is a major component of adherens junctions and marks Langerhans cells (LC), the only dendritic cell (DC) population of the epidermis. LC form a dense network and attach themselves to the surrounding keratinocytes via homophilic E-cadherin binding. LC activation, mobilization, and migration require a reduction in LC E-cadherin expression. To determine whether E-cadherin plays a role in regulating LC homeostasis and function, we generated CD11c-specific E-cadherin knockout mice (CD11c-Ecad
Identifiants
pubmed: 31260672
pii: S0022-202X(19)31799-3
doi: 10.1016/j.jid.2019.06.132
pii:
doi:
Substances chimiques
CD11c Antigen
0
Cadherins
0
Imiquimod
P1QW714R7M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
132-142.e3Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.