Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor.
Adult
Biomarkers
Cellular Senescence
/ immunology
Decidua
/ immunology
Female
Humans
Immunophenotyping
Labor, Obstetric
/ immunology
Leukocytes
/ immunology
Lymphocyte Count
Maternal-Fetal Exchange
/ immunology
Obstetric Labor, Premature
/ immunology
Placenta
/ immunology
Pregnancy
T-Lymphocyte Subsets
/ immunology
T-Lymphocytes
/ immunology
Young Adult
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2019
2019
Historique:
received:
21
12
2018
accepted:
07
02
2019
entrez:
3
7
2019
pubmed:
3
7
2019
medline:
19
12
2019
Statut:
epublish
Résumé
Successful pregnancy requires a tightly-regulated equilibrium of immune cell interactions at the maternal-fetal interface (i.e., the decidual tissues), which plays a central role in the inflammatory process of labor. Most of the innate immune cells in this compartment have been well characterized; however, adaptive immune cells are still under investigation. Herein, we performed immunophenotyping of the decidua basalis and decidua parietalis to determine whether exhausted and senescent T cells are present at the maternal-fetal interface and whether the presence of pathological (i.e., preterm) or physiological (i.e., term) labor and/or placental inflammation alter such adaptive immune cells. In addition, decidual exhausted T cells were sorted to test their functional status. We found that (1) exhausted and senescent T cells were present at the maternal-fetal interface and predominantly expressed an effector memory phenotype, (2) exhausted CD4
Identifiants
pubmed: 31263712
doi: 10.1155/2019/3128010
pmc: PMC6556261
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3128010Subventions
Organisme : NICHD NIH HHS
ID : HHSN275201300006C
Pays : United States
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