MERTK Acts as a Costimulatory Receptor on Human CD8

Biomarkers CD8-Positive T-Lymphocytes / immunology Calcium-Binding Proteins / genetics Cytokines / metabolism Energy Metabolism Gene Expression Humans Immunophenotyping Lymphocyte Activation / immunology Lymphocytes, Tumor-Infiltrating Melanoma / genetics Protein S Signal Transduction T-Lymphocyte Subsets / immunology c-Mer Tyrosine Kinase / metabolism

Journal

Cancer immunology research
ISSN: 2326-6074
Titre abrégé: Cancer Immunol Res
Pays: United States
ID NLM: 101614637

Informations de publication

Date de publication:
Sep 2019
Historique:
received: 26 11 2018
revised: 14 03 2019
accepted: 27 06 2019
pubmed: 4 7 2019
medline: 8 9 2020
entrez: 4 7 2019
Statut: ppublish

Résumé

The TAM family of receptor tyrosine kinases (TYRO3, AXL, and MERTK) is known to be expressed on antigen-presenting cells and function as oncogenic drivers and as inhibitors of inflammatory responses. Both human and mouse CD8

Identifiants

DOI: 10.1158/2326-6066.CIR-18-0841 PMID: 31266785
pubmed: 31266785
pii: 2326-6066.CIR-18-0841
doi: 10.1158/2326-6066.CIR-18-0841
doi:

Substances chimiques

Biomarkers 0
Calcium-Binding Proteins 0
Cytokines 0
PROS1 protein, human 0
Protein S 0
MERTK protein, human EC 2.7.10.1
c-Mer Tyrosine Kinase EC 2.7.10.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1472-1484

Informations de copyright

©2019 American Association for Cancer Research.

Auteurs

Marlies J W Peeters (MJW)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark. per.thor.straten@regionh.dk marlies.peeters@regionh.dk.
ORCID: 0000-0002-7106-7216

Donata Dulkeviciute (D)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.

Arianna Draghi (A)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.
ORCID: 0000-0002-5894-6750

Cathrin Ritter (C)

Translational Skin Cancer Research, University Hospital Essen, German Cancer Consortium (DKTK) Partner Site Essen and German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0001-7027-8292

Anne Rahbech (A)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.

Signe K Skadborg (SK)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.

Tina Seremet (T)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.

Ana Micaela Carnaz Simões (AM)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.

Evelina Martinenaite (E)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.

Hólmfridur R Halldórsdóttir (HR)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.
ORCID: 0000-0002-9033-2716

Mads Hald Andersen (MH)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.
ORCID: 0000-0002-2914-9605

Gitte Holmen Olofsson (GH)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.
ORCID: 0000-0002-7060-8754

Inge Marie Svane (IM)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.
Department of Oncology, University Hospital Herlev, Copenhagen, Denmark.

Lene Juel Rasmussen (LJ)

Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Denmark.

Özcan Met (Ö)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.
Department of Oncology, University Hospital Herlev, Copenhagen, Denmark.
Department of Immunology and Microbiology, Inflammation and Cancer Group, University of Copenhagen, Copenhagen, Denmark.

Jürgen C Becker (JC)

Translational Skin Cancer Research, University Hospital Essen, German Cancer Consortium (DKTK) Partner Site Essen and German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0001-9183-653X

Marco Donia (M)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark.
Department of Oncology, University Hospital Herlev, Copenhagen, Denmark.

Claus Desler (C)

Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Denmark.
ORCID: 0000-0002-0125-004X

Per Thor Straten (P)

Department of Hematology, Center for Cancer Immune Therapy, University Hospital Herlev, Copenhagen, Denmark. per.thor.straten@regionh.dk marlies.peeters@regionh.dk.
Department of Immunology and Microbiology, Inflammation and Cancer Group, University of Copenhagen, Copenhagen, Denmark.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes TIL › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Facteurs biologiques › Inhibiteurs des facteurs de la coagulation sanguine › Protéine S › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › MERTK Acts as a Costimulatory Receptor on Human CD8
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › c-Mer Tyrosine kinase › MERTK Acts as a Costimulatory Receptor on Human CD8