Risk of secondary haematological malignancies in patients with follicular lymphoma: an analysis of 1028 patients treated in the rituximab era.
Adolescent
Adult
Aged
Aged, 80 and over
Disease-Free Survival
Female
Follow-Up Studies
Hematologic Neoplasms
/ drug therapy
Humans
Lymphoma, Follicular
/ drug therapy
Male
Middle Aged
Neoplasms, Second Primary
/ drug therapy
Registries
Retrospective Studies
Risk Factors
Rituximab
/ administration & dosage
Survival Rate
follicular lymphoma
late effects of therapy
secondary haematological malignancies
secondary leukaemia
treatment related cancer
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
27
03
2019
accepted:
21
05
2019
pubmed:
4
7
2019
medline:
17
6
2020
entrez:
4
7
2019
Statut:
ppublish
Résumé
Follicular lymphoma (FL) is the most common indolent lymphoma. Currently there are many comparable treatment options available for FL. When selecting the most optimal therapy it is important to consider possible late effects of the treatment as well as survival. Secondary haematological malignancy (SHM) is a severe late effect of treatments, but the incidence of SHMs is still largely unknown. The goal of the present study was to determine the incidence of SHMs and how therapeutic decisions interfere with this risk. The study included 1028 FL patients with a median follow-up time of 5·6 years. The 5-year risk of SHM was 1·1% and the risk was associated with multiple lines of treatment (P = 0·016). The 5-year risk of SHM was 0·5% after the first-line treatment and 1·6% after the second-line. The standardized incidence ratio (SIR) was 6·2 (95% confidence interval 3·4-10·5) for SHM overall. This retrospective study found that the risk of SHM was low after first-line treatment in FL patients from the rituximab era. However, the risk of SHM increases with multiple lines of treatment. Therapeutic approaches should aim to achieve as long a remission as possible with first-line treatment, thereby postponing the added risk of SHM.
Substances chimiques
Rituximab
4F4X42SYQ6
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
364-371Informations de copyright
© 2019 British Society for Haematology and John Wiley & Sons Ltd.
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