Statins can suppress DC-mediated Th2 responses through the repression of OX40-ligand and CCL17 expression.
Antibodies, Neutralizing
/ pharmacology
CD28 Antigens
/ genetics
CD3 Complex
/ genetics
Cell Proliferation
/ drug effects
Chemokine CCL17
/ antagonists & inhibitors
Coculture Techniques
Cytokines
/ pharmacology
Dendritic Cells
/ cytology
Gene Expression Regulation
/ drug effects
Humans
Immunologic Memory
/ drug effects
Interferon-gamma
/ genetics
Interleukins
/ genetics
NF-kappa B p50 Subunit
/ genetics
OX40 Ligand
/ antagonists & inhibitors
Primary Cell Culture
Quinolines
/ pharmacology
Signal Transduction
Simvastatin
/ pharmacology
Th2 Cells
/ cytology
Tumor Necrosis Factor-alpha
/ genetics
Thymic Stromal Lymphopoietin
CCL17
OX40L
myeloid DCs
statin
thymic stromal lymphopoietin (TSLP)
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
02
11
2018
revised:
16
05
2019
accepted:
28
06
2019
pubmed:
4
7
2019
medline:
27
5
2020
entrez:
4
7
2019
Statut:
ppublish
Résumé
DCs and epithelial cell-derived thymic stromal lymphopoietin (TSLP) have pivotal roles in allergic inflammation. TSLP stimulates myeloid DCs to express OX40-ligand (OX40L) and CCL17, which trigger and maintain Th2 cell responses. We have previously shown that statins, which are HMG-CoA reductase inhibitors, have the ability to suppress type I IFN production by plasmacytoid DCs. Here, we extended our previous work to examine the immunomodulatory effect of statins on allergic responses, particularly the TSLP-dependent Th2 pathway induced by myeloid DCs. We found that treatment of TSLP-stimulated DCs with either pitavastatin or simvastatin suppressed both the DC-mediated inflammatory Th2 cell differentiation and CRTH2
Identifiants
pubmed: 31269241
doi: 10.1002/eji.201847992
pmc: PMC6899642
doi:
Substances chimiques
Antibodies, Neutralizing
0
CCL17 protein, human
0
CD28 Antigens
0
CD3 Complex
0
Chemokine CCL17
0
Cytokines
0
Interleukins
0
NF-kappa B p50 Subunit
0
OX40 Ligand
0
Quinolines
0
TNFSF4 protein, human
0
Tumor Necrosis Factor-alpha
0
Interferon-gamma
82115-62-6
Simvastatin
AGG2FN16EV
pitavastatin
M5681Q5F9P
Thymic Stromal Lymphopoietin
GT0IL38SP4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2051-2062Informations de copyright
© 2019 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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