Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response.

Animals Antigens / immunology Bone Marrow Cells / metabolism Coinfection / immunology Cytokines / metabolism Dendritic Cells / cytology Female Gastritis / immunology Helicobacter Infections / immunology Helicobacter pylori Humans Interferon-gamma / metabolism Liver / metabolism Liver Cirrhosis / metabolism Mice Mice, Inbred C57BL Schistosomiasis mansoni / immunology Stomach / immunology Th1 Cells / immunology Th2 Cells / immunology
Helicobacter pylori Schistosoma mansoni chronic disease co-infection immune misdirection liver

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
02 07 2019
Historique:
received: 02 08 2018
revised: 29 01 2019
accepted: 29 05 2019
entrez: 4 7 2019
pubmed: 4 7 2019
medline: 28 8 2020
Statut: ppublish

Résumé

Helicobacter pylori chronically colonizes the stomach and is strongly associated with gastric cancer. Its concomitant occurrence with helminths such as schistosomes has been linked to reduced cancer incidence, presumably due to suppression of H. pylori-associated pro-inflammatory responses. However, experimental evidence in support of such a causal link or the mutual interaction of both pathogens is lacking. We investigated the effects of co-infection during the different immune phases of S. mansoni infection. Surprisingly, co-infected mice had increased H. pylori gastric colonization during the interferon gamma (IFNγ) phase of schistosome infection but reduced infiltration of T cells in the stomach due to misdirection of antigen-experienced CXCR3

Identifiants

DOI: 10.1016/j.celrep.2019.05.108 PMID: 31269443
pubmed: 31269443
pii: S2211-1247(19)30755-7
doi: 10.1016/j.celrep.2019.05.108
pii:
doi:

Substances chimiques

Antigens 0
Cytokines 0
Interferon-gamma 82115-62-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

231-244.e5

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Sonakshi Bhattacharjee (S)

Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany; German Centre for Infection Research (DZIF), partner site Munich, Munich, Germany.

Raquel Mejías-Luque (R)

Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany; German Centre for Infection Research (DZIF), partner site Munich, Munich, Germany.

Eva Loffredo-Verde (E)

Institute for Virology, Technical University of Munich, Munich, Germany.

Albulena Toska (A)

Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany.

Michael Flossdorf (M)

Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany.

Markus Gerhard (M)

Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany; German Centre for Infection Research (DZIF), partner site Munich, Munich, Germany. Electronic address: markus.gerhard@tum.de.

Clarissa Prazeres da Costa (C)

Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany. Electronic address: clarissa.dacosta@tum.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Facteurs biologiques › Antigènes › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Infection › Co-infection › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Gastrite › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Helicobacter › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Bactéries › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Système digestif › Foie › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cirrhose du foie › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Infection › Maladies vectorielles › Schistosomiase › Schistosomiase à Schistosoma mansoni › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif supérieur › Estomac › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › Concomitant Infection of S. mansoni and H....
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th2 › Concomitant Infection of S. mansoni and H....