Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein.
Adolescent
Adult
Antigens, Bacterial
/ immunology
Autoantibodies
/ blood
Bacterial Proteins
/ immunology
Blood Bactericidal Activity
Complement Factor H
/ immunology
Humans
Meningococcal Vaccines
/ administration & dosage
Neisseria meningitidis, Serogroup B
/ immunology
Prospective Studies
Serogroup
Young Adult
4C-MenB
Bexsero
FHbp
MenB-4C
Neisseria meningitidis
factor H
vaccines
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
03 07 2019
03 07 2019
Historique:
entrez:
5
7
2019
pubmed:
5
7
2019
medline:
23
2
2020
Statut:
epublish
Résumé
Meningococcal serogroup B (MenB) vaccines contain recombinant factor H binding protein (FHbp), which can complex with complement factor H (CFH) and thereby risk eliciting anti-FH autoantibodies. While anti-FH antibodies can be present in sera of healthy persons, the antibodies are implicated in autoimmune atypical hemolytic uremic syndrome and C3 glomerulopathies. We immunized 120 students with a MenB vaccine (Bexsero). By enzyme-linked immunosorbent assay (ELISA), there were small increases in serum anti-FH levels at 3 weeks postvaccination (geometric mean optical density at 405 nm [OD
Identifiants
pubmed: 31270173
pii: 4/4/e00393-19
doi: 10.1128/mSphere.00393-19
pmc: PMC6609231
pii:
doi:
Substances chimiques
4CMenB vaccine
0
Antigens, Bacterial
0
Autoantibodies
0
Bacterial Proteins
0
CFH protein, human
0
Meningococcal Vaccines
0
factor H-binding protein, Neisseria meningitidis
0
Complement Factor H
80295-65-4
Banques de données
ClinicalTrials.gov
['NCT02583412']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI114701
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI134868
Pays : United States
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2019 Sharkey et al.
Références
Blood. 2007 Sep 1;110(5):1516-8
pubmed: 17495132
Clin Infect Dis. 2017 Oct 1;65(7):1112-1119
pubmed: 28582542
mBio. 2014 Aug 26;5(5):e01625-14
pubmed: 25161192
J Immunol. 2006 Jun 15;176(12):7566-75
pubmed: 16751403
Clin Infect Dis. 2019 Sep 13;69(7):1101-1111
pubmed: 30551148
Lancet. 1983 Aug 13;2(8346):355-7
pubmed: 6135869
Immunobiology. 2014 Jan;219(1):9-16
pubmed: 23891327
J Proteome Res. 2013 Apr 5;12(4):1898-908
pubmed: 23410224
PLoS Genet. 2007 Mar 16;3(3):e41
pubmed: 17367211
AAPS J. 2016 Nov;18(6):1562-1575
pubmed: 27604766
J Am Soc Nephrol. 2005 Feb;16(2):555-63
pubmed: 15590760
Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6873-8
pubmed: 26501415
J Infect Dis. 2019 Mar 15;219(7):1130-1137
pubmed: 30346576
JCI Insight. 2016 Sep 08;1(14):e88907
pubmed: 27668287
Pediatr Res. 2009 Sep;66(3):336-40
pubmed: 19531976
Pediatr Nephrol. 2017 Jan;32(1):43-57
pubmed: 27056062
Mol Immunol. 2004 May;41(1):81-4
pubmed: 15140578
Nephrol Dial Transplant. 2010 Jan;25(1):136-44
pubmed: 19666655
Clin Vaccine Immunol. 2008 May;15(5):799-804
pubmed: 18353918
Mol Immunol. 2013 Dec 15;56(3):213-21
pubmed: 23790637
Blood. 2008 Feb 1;111(3):1512-4
pubmed: 18006700
Hum Vaccin Immunother. 2018;14(11):2802
pubmed: 29883245
Clin Vaccine Immunol. 2017 Jan 5;24(1):
pubmed: 27847367
Clin Vaccine Immunol. 2006 Jun;13(6):605-10
pubmed: 16760316
Clin Vaccine Immunol. 2014 Nov;21(11):1505-11
pubmed: 25185576
J Intern Med. 2015 Mar;277(3):294-305
pubmed: 25495259
J Infect. 2015 Sep;71(3):326-37
pubmed: 25982025
Ann Med. 2006;38(8):592-604
pubmed: 28950782
Clin Nephrol. 2015 Jan;83(1):49-56
pubmed: 24131678
Cell Mol Life Sci. 2017 May;74(9):1605-1624
pubmed: 27942748
J Immunol. 2012 May 15;188(10):5063-72
pubmed: 22504643
Semin Nephrol. 2013 Nov;33(6):508-30
pubmed: 24161037
Hum Mol Genet. 2014 Oct 1;23(19):5283-93
pubmed: 24847005
Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5858-63
pubmed: 20592223
J Immunol. 2012 Aug 15;189(4):1858-67
pubmed: 22786770
MMWR Morb Mortal Wkly Rep. 2010 Nov 19;59(45):1480-3
pubmed: 21085089
mBio. 2019 Jun 18;10(3):
pubmed: 31213564
Infect Immun. 2009 Feb;77(2):764-9
pubmed: 19047406
Clin Kidney J. 2012 Apr;5(2):133-136
pubmed: 29497514
Vaccine. 2018 Aug 23;36(35):5309-5317
pubmed: 30061029
J Immunol. 2015 Jun 1;194(11):5129-38
pubmed: 25917093
Vaccine. 2015 Dec 16;33(51):7168-7175
pubmed: 26562320
J Immunol. 2012 Oct 1;189(7):3528-37
pubmed: 22922817
Emerg Infect Dis. 2018 Aug;24(8):
pubmed: 30015608
Arthritis Res Ther. 2012 Aug 15;14(4):R185
pubmed: 22894814
Lancet Infect Dis. 2017 Jan;17(1):58-67
pubmed: 27745812
J Immunol. 2011 Mar 15;186(6):3606-14
pubmed: 21325619
MMWR Morb Mortal Wkly Rep. 2015 Oct 23;64(41):1171-6
pubmed: 26492381
Vaccine. 2018 May 3;36(19):2507-2509
pubmed: 29631884