Liraglutide Attenuates Preestablished Atherosclerosis in Apolipoprotein E-Deficient Mice via Regulation of Immune Cell Phenotypes and Proinflammatory Mediators.

Animals Apolipoproteins E / deficiency Chemokines / metabolism Disease Progression Female Humans Inflammation Mediators / metabolism Liraglutide / pharmacology Male Mice Phenotype Plaque, Atherosclerotic / drug therapy

Journal

The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362

Informations de publication

Date de publication:
09 2019
Historique:
received: 03 04 2019
accepted: 26 06 2019
pubmed: 5 7 2019
medline: 31 12 2019
entrez: 5 7 2019
Statut: ppublish

Résumé

We have shown that the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide (Lir) inhibits development of early atherosclerosis in vivo by modulating immune cell function. We hypothesized that Lir could attenuate pre-established disease by modulating monocyte or macrophage phenotype to induce atheroprotective responses. Human atherosclerotic plaques obtained postendarterectomy and human peripheral blood macrophages were treated ex vivo with Lir. In parallel, apolipoprotein E-deficient (ApoE

Identifiants

DOI: 10.1124/jpet.119.258343 PMID: 31270216
pubmed: 31270216
pii: jpet.119.258343
doi: 10.1124/jpet.119.258343
doi:

Substances chimiques

Apolipoproteins E 0
Chemokines 0
Inflammation Mediators 0
Liraglutide 839I73S42A

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

447-458

Informations de copyright

Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Robyn Bruen (R)

School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland.

Seán Curley (S)

School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland.

Sarina Kajani (S)

School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland.

Gina Lynch (G)

School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland.

Marcella E O'Reilly (ME)

School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland.

Eugène T Dillon (ET)

School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland.

Eoin P Brennan (EP)

School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland.

Mary Barry (M)

School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland.

Stephen Sheehan (S)

School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland.

Fiona C McGillicuddy (FC)

School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland.
ORCID: 0000-0003-3623-3503

Orina Belton (O)

School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland orina.belton@ucd.ie.
ORCID: 0000-0002-7701-6540

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Liraglutide Attenuates Preestablished...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Liraglutide Attenuates Preestablished...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Liraglutide Attenuates Preestablished...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Liraglutide Attenuates Preestablished...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Liraglutide Attenuates Preestablished...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Liraglutide Attenuates Preestablished...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › Liraglutide › Liraglutide Attenuates Preestablished...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Liraglutide Attenuates Preestablished...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Liraglutide Attenuates Preestablished...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › Liraglutide Attenuates Preestablished...