Neuroepigenetic signatures of age and sex in the living human brain.
Adamantane
/ analogs & derivatives
Adolescent
Adult
Age Factors
Aged
Brain
/ diagnostic imaging
Carbon Radioisotopes
/ pharmacokinetics
Emotions
Epigenesis, Genetic
Female
Histone Deacetylase 1
/ metabolism
Histone Deacetylase 2
/ metabolism
Humans
Hydroxamic Acids
/ pharmacokinetics
Male
Middle Aged
Sex Characteristics
Tissue Donors
White Matter
/ anatomy & histology
Young Adult
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
03 07 2019
03 07 2019
Historique:
received:
23
04
2019
accepted:
06
06
2019
entrez:
5
7
2019
pubmed:
5
7
2019
medline:
11
9
2019
Statut:
epublish
Résumé
Age- and sex-related alterations in gene transcription have been demonstrated, however the underlying mechanisms are unresolved. Neuroepigenetic pathways regulate gene transcription in the brain. Here, we measure in vivo expression of the epigenetic enzymes, histone deacetylases (HDACs), across healthy human aging and between sexes using [
Identifiants
pubmed: 31270332
doi: 10.1038/s41467-019-11031-0
pii: 10.1038/s41467-019-11031-0
pmc: PMC6610136
doi:
Substances chimiques
Carbon Radioisotopes
0
Carbon-11
0
Hydroxamic Acids
0
martinostat
8JJC99KHGL
Histone Deacetylase 1
EC 3.5.1.98
Histone Deacetylase 2
EC 3.5.1.98
Adamantane
PJY633525U
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2945Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH108574
Pays : International
Organisme : NIH HHS
ID : S10 OD023517
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB)
ID : P41EB015896
Pays : International
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R21MH11197101A1
Pays : International
Organisme : NIMH NIH HHS
ID : R03 MH110745
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR017208
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH102377
Pays : International
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R03MH110745
Pays : International
Organisme : NIMH NIH HHS
ID : R01 MH108574
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023043
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015902
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR022976
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : K24MH110807
Pays : International
Organisme : NIMH NIH HHS
ID : R01 MH102377
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH111971
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA030321
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH110807
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR026666
Pays : United States
Organisme : NIDA NIH HHS
ID : R00 DA037928
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
ID : R00DA037928
Pays : International
Organisme : U.S. Department of Energy (DOE)
ID : DE-SC0008430
Pays : International
Organisme : NCRR NIH HHS
ID : S10 RR019933
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015896
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023401
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB)
ID : P41EB015902
Pays : International
Références
Nature. 2007 May 10;447(7141):178-82
pubmed: 17468743
Am J Psychiatry. 1997 Dec;154(12):1641-7
pubmed: 9396940
Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5605-10
pubmed: 20212170
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
Neuroimage. 2015 Jun;113:184-95
pubmed: 25776214
ACS Chem Neurosci. 2014 Oct 15;5(10):1055-62
pubmed: 25188794
Nat Neurosci. 2017 Sep;20(9):1247-1259
pubmed: 28783139
PLoS One. 2013 Aug 14;8(8):e71323
pubmed: 23967191
Nat Rev Neurosci. 2006 Jan;7(1):30-40
pubmed: 16371948
J Clin Invest. 2015 Sep;125(9):3572-84
pubmed: 26280576
MAGMA. 2009 Feb;22(1):63-70
pubmed: 18810519
Cell. 1993 Jul 30;74(2):281-9
pubmed: 8343956
Sci Rep. 2016 Feb 16;6:21181
pubmed: 26880485
Curr Alzheimer Res. 2013 Oct;10(8):868-76
pubmed: 24093534
Epigenetics. 2011 Jul;6(7):857-61
pubmed: 21617370
Epigenetics. 2009 Jan;4(1):47-53
pubmed: 19029819
Neuroimage. 2014 May 15;92:381-97
pubmed: 24530839
Endocrinology. 2011 Jul;152(7):2760-7
pubmed: 21586557
Nat Commun. 2017 Jan 31;8:14272
pubmed: 28139683
Nat Neurosci. 2018 Jun;21(6):811-819
pubmed: 29802388
PLoS One. 2012;7(3):e33249
pubmed: 22438904
Nat Neurosci. 2009 Jul;12(7):829-38
pubmed: 19503085
Neuroimage Clin. 2015 Jan 19;7:409-14
pubmed: 25685708
J Neurosci. 2009 Sep 16;29(37):11451-60
pubmed: 19759294
Mol Neurobiol. 2018 Mar;55(3):2432-2442
pubmed: 28364391
Biogerontology. 2014 Aug;15(4):339-46
pubmed: 24924148
Nat Commun. 2013;4:2771
pubmed: 24264146
Nat Neurosci. 2015 Oct;18(10):1413-20
pubmed: 26404716
Hum Mol Genet. 2018 Feb 15;27(4):732-741
pubmed: 29228364
Neuroimage Clin. 2017 Jan 23;14:156-165
pubmed: 28180074
Neurosci Biobehav Rev. 2018 Jul;90:350-370
pubmed: 29684403
Nature. 1996 Dec 12;384(6609):589-91
pubmed: 8955276
Nat Neurosci. 2008 Sep;11(9):1024-34
pubmed: 19160500
Rev Neurosci. 2010;21(3):187-221
pubmed: 20879692
N Engl J Med. 1996 Jan 11;334(2):71-6
pubmed: 8531961
Neurosci Lett. 2013 Nov 27;556:152-4
pubmed: 24140005
J Neurosci. 2015 Aug 19;35(33):11729-42
pubmed: 26290249
Exp Neurol. 2013 Mar;241:56-66
pubmed: 23261766
ACS Cent Sci. 2017 Sep 27;3(9):1006-1014
pubmed: 28979942
Neuroimage. 2016 May 15;132:334-343
pubmed: 26915497
Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12325-30
pubmed: 21746928
Biol Psychiatry. 2007 Oct 15;62(8):847-55
pubmed: 17544382
Mol Neurobiol. 2017 Dec;54(10):8263-8277
pubmed: 27914010
Sci Transl Med. 2016 Aug 10;8(351):351ra106
pubmed: 27510902
Science. 2010 May 7;328(5979):753-6
pubmed: 20448184
Nature. 2009 May 7;459(7243):55-60
pubmed: 19424149
Neurosci Lett. 2011 Apr 15;493(3):122-6
pubmed: 21335060
Neuropsychopharmacology. 2010 Mar;35(4):870-80
pubmed: 20010553
Nature. 2012 Feb 29;483(7388):222-6
pubmed: 22388814
Nature. 2015 Feb 19;518(7539):365-9
pubmed: 25693568
Brain. 2015 Mar;138(Pt 3):604-15
pubmed: 25582579
J Clin Invest. 2019 Jan 2;129(1):364-372
pubmed: 30530989
Cell. 2014 Jan 16;156(1-2):261-76
pubmed: 24439381
Neuroimage. 2010 May 15;51(1):242-51
pubmed: 20149879
J Neurosci. 2011 Mar 16;31(11):3990-9
pubmed: 21411642
Nature. 2004 Jun 24;429(6994):883-91
pubmed: 15190254
J Med Chem. 2014 Oct 9;57(19):7999-8009
pubmed: 25203558
J Neural Transm (Vienna). 2017 Aug;124(8):901-905
pubmed: 28150045
Hum Brain Mapp. 2006 May;27(5):380-91
pubmed: 16565953
Neuropsychopharmacology. 2015 Jun;40(7):1692-9
pubmed: 25578798
Nature. 2014 Mar 27;507(7493):448-54
pubmed: 24670762
Nat Neurosci. 2018 Apr;21(4):497-505
pubmed: 29507413
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Arch Neurol. 2003 Jul;60(7):989-94
pubmed: 12873856
Neuroimage. 2018 Nov 15;182:259-282
pubmed: 29729390
Neuron. 2007 Jul 19;55(2):217-30
pubmed: 17640524
ACS Chem Neurosci. 2015 May 20;6(5):708-15
pubmed: 25768025
Nat Neurosci. 2012 Sep;15(9):1245-54
pubmed: 22864611
Nat Neurosci. 2011 Apr;14(4):437-41
pubmed: 21423191
Brain Res. 2002 Nov 8;954(2):173-82
pubmed: 12414100
Trends Cogn Sci. 2018 Jun;22(6):504-516
pubmed: 29628441
Biol Psychiatry. 2007 Jul 1;62(1):55-64
pubmed: 16945350
Endocrinology. 2010 Mar;151(3):1212-20
pubmed: 20051490
Nat Neurosci. 2011 Apr;14(4):429-36
pubmed: 21423190
Arch Neurol. 1999 May;56(5):587-92
pubmed: 10328254
EMBO J. 2004 Aug 18;23(16):3336-45
pubmed: 15297880
Emotion. 2003 Mar;3(1):97-105
pubmed: 12899321