Feasibility of INTACT (INcisionless TArgeted Core Tissue) biopsy procedure for perinatal autopsy.
autopsy
minimally invasive autopsy
pediatric
perinatal
ultrasound
Journal
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
ISSN: 1469-0705
Titre abrégé: Ultrasound Obstet Gynecol
Pays: England
ID NLM: 9108340
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
30
03
2019
revised:
18
06
2019
accepted:
21
06
2019
pubmed:
5
7
2019
medline:
27
11
2021
entrez:
5
7
2019
Statut:
ppublish
Résumé
To determine the feasibility and tissue yield of a perinatal incisionless ultrasound-guided biopsy procedure, the INcisionless Targeted Core Tissue (INTACT) technique, in the context of minimally invasive autopsy. Cases of perinatal death in which the parents consented for minimally invasive autopsy underwent postmortem magnetic resonance imaging and an INTACT biopsy procedure, defined as needle biopsy of organs via the umbilical cord, performed under ultrasound guidance. In each case, three cores of tissue were obtained from seven target organs (both lungs, both kidneys, heart, spleen and liver). Biopsy success was predefined as an adequate volume of the intended target organ for pathological analysis, as judged by a pathologist blinded to the case and biopsy procedure. Thirty fetuses underwent organ sampling. Mean gestational age was 30 weeks (range, 18-40 weeks) and mean delivery-to-biopsy interval was 12 days (range, 6-22 days). The overall biopsy success rate was 153/201 (76.1%) samples, with the success rates in individual organs being highest for the heart and lungs (93% and 91%, respectively) and lowest for the spleen (11%). Excluding splenic samples, the biopsy success rate was 150/173 (86.7%). Histological abnormalities were found in 4/201 (2%) samples, all of which occurred in the lungs and kidneys of a fetus with pulmonary hypoplasia and multicystic kidney disease. Incisionless ultrasound-guided organ biopsy using the INTACT procedure is feasible, with an overall biopsy success rate of over 75%. This novel technique offers the ideal combination of an imaging-led autopsy with organ sampling for parents who decline the conventional invasive approach. © 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.
Identifiants
pubmed: 31271478
doi: 10.1002/uog.20387
pmc: PMC7317589
doi:
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
667-675Subventions
Organisme : Department of Health
ID : 14/168/02
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R002118/1
Pays : United Kingdom
Organisme : National Institute for Health Research
ID : NIHR-CDF-2017-10-037
Organisme : Pathological Society of Great Britain and Ireland
Organisme : Department of Health
ID : CDF-2017-10-037
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R00218/1
Pays : United Kingdom
Organisme : Royal College of Radiologists
ID : MR/R00218/1
Organisme : National Institute for Health Research
ID : Senior Investigator Award
Organisme : Great Ormond Street Hospital Charity
Organisme : Department of Health
ID : NIHR-CS-012-002
Pays : United Kingdom
Organisme : Department of Health
ID : ICA-CDRF-2017-03-053
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.
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