Long-term recurrences of jaw osteoradionecrosis after apparent healing with the PENTOCLO protocol.

Clodronic Acid Drug Combinations Head and Neck Neoplasms / radiotherapy Humans Neoplasm Recurrence, Local Osteoradionecrosis / diagnosis Pentoxifylline Tocopherols
Osteoradionecrosis PENTO PENTOCLO

Journal

Journal of stomatology, oral and maxillofacial surgery
ISSN: 2468-7855
Titre abrégé: J Stomatol Oral Maxillofac Surg
Pays: France
ID NLM: 101701089

Informations de publication

Date de publication:
Jun 2020
Historique:
received: 16 06 2019
accepted: 21 06 2019
pubmed: 5 7 2019
medline: 25 9 2020
entrez: 5 7 2019
Statut: ppublish

Résumé

Osteoradionecrosis of the jaws (ORNJ) is a late complication of head and neck irradiation estimated at around 3% of irradiated patients. The PENTO protocol (Pentoxyfilline and Tocopherol), with the eventual adjunction of Clodronate (PENTOCLO), showed interesting results even in advanced ORNJ. The current literature does not describe the long-term outcomes and particularly after the completion of the protocol. The PENTO or PENTOCLO protocol should be prescribed as a life-long treatment or the outcome should be monitored at least as long as the duration of the protocol after its end.

Identifiants

DOI: 10.1016/j.jormas.2019.06.007 PMID: 31271892
pubmed: 31271892
pii: S2468-7855(19)30163-6
doi: 10.1016/j.jormas.2019.06.007
pii:
doi:

Substances chimiques

Drug Combinations 0
pentoxifylline-tocopherol-clodronate 0
Clodronic Acid 0813BZ6866
Tocopherols R0ZB2556P8
Pentoxifylline SD6QCT3TSU

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

286-287

Informations de copyright

Copyright © 2019 Elsevier Masson SAS. All rights reserved.

Auteurs

A Dinnoo (A)

Department of Head and Neck Oncology, Gustave Roussy Institute, université Paris-Saclay, 14, rue Édouard Vaillant, 94800 Villejuif, France.

F Bidault (F)

Department of Radiology, Institut Gustave-Roussy, 14, rue Édouard Vaillant, 94800 Villejuif, France; IR4M, UMR 8081, CNRS, université Paris-Sud, université Paris-Saclay, 91400 Orsay, France.

N Lassau (N)

Department of Radiology, Institut Gustave-Roussy, 14, rue Édouard Vaillant, 94800 Villejuif, France; IR4M, UMR 8081, CNRS, université Paris-Sud, université Paris-Saclay, 91400 Orsay, France.

M Elmaalouf (M)

Department of Odontology, Gustave Roussy Institute, université Paris-Saclay, 14, rue Édouard Vaillant, 94800 Villejuif, France.

A Moya-Plana (A)

Department of Head and Neck Oncology, Gustave Roussy Institute, université Paris-Saclay, 14, rue Édouard Vaillant, 94800 Villejuif, France.

A Ruffier (A)

Department of Radiotherapy, Gustave Roussy Institute, université Paris-Saclay, 14, rue Édouard Vaillant, 94800 Villejuif, France.

F Janot (F)

Department of Head and Neck Oncology, Gustave Roussy Institute, université Paris-Saclay, 14, rue Édouard Vaillant, 94800 Villejuif, France.

N Benmoussa (N)

Department of Head and Neck Oncology, Gustave Roussy Institute, université Paris-Saclay, 14, rue Édouard Vaillant, 94800 Villejuif, France. Electronic address: nadia.benmoussa@yahoo.fr.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Diphosphonates › Acide clodronique › Long-term recurrences of jaw...
questionsmedicales.fr › Préparations pharmaceutiques › Association médicamenteuse › Long-term recurrences of jaw...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Long-term recurrences of jaw...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Long-term recurrences of jaw...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Long-term recurrences of jaw...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Ostéoradionécrose › Long-term recurrences of jaw...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Xanthines › Théobromine › Pentoxifylline › Long-term recurrences of jaw...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Vitamine E › Tocophérols › Long-term recurrences of jaw...